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BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt)

(Synonyms: BAM 8-22, Bovine Adrenal Medulla 8-22) 目录号 : GC52409

A neuropeptide and MRGPRX1 agonist

BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt) Chemical Structure

规格 价格 库存 购买数量
1 mg
¥4,606.00
现货
5 mg
¥14,980.00
现货
10 mg
¥23,030.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

BAM-22P (8-22) is an endogenous neuropeptide derived from proenkephalin A and an agonist of MAS-related G protein-coupled receptor family member X1 (MRGPRX1), previously known as sensory neuron-specific G protein-coupled receptor 4 (SNSR4).1 It is involved in prurition and nociception. BAM-22P (8-22) induces calcium mobilization in HEK293S cells expressing human MRGPRX1 or SNSR3 (EC50s = 14 and 28 nM, respectively) and inhibits voltage-induced calcium currents in isolated rat neurons expressing human MRGPRX1 (EC50 = 0.6 µM).2 Intrathecal administration of BAM-22P (8-22) (30 nmol/animal) decreases the tail-flick latency in rats stimulated with the Gαi inhibitor pertussin toxin and increases the tail-flick latency in rats stimulated with the phospholipase C (PLC) inhibitor U-73122, indicating changes in pain sensitivity.3 BAM-22P (8-22) (100 µg/animal) increases scratching behavior in wild-type mice and enhances bile-duct ligation-induced scratching behavior in a mouse model of cholestasis.4

1.Lembo, P.M.C., Grazzini, E., Groblewski, T., et al.Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRsNat. Neurosci.5(3)201-209(2002) 2.Chen, H., and Ikeda, S.R.Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neuronsJ. Neurosci.24(21)5044-5053(2004) 3.Chen, T., Wang, D., and Hong, Y.Dual modulation effects of Mas-related gene (Mrg) receptors on pain sensitivity in ratsNeurosci. Lett.514(1)82-85(2012) 4.Sanjel, B., Maeng, H.-J., and Shim, W.-S.BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritusSci. Rep.9(1)10888(2019)

Chemical Properties

Cas No. SDF Download SDF
别名 BAM 8-22, Bovine Adrenal Medulla 8-22
Canonical SMILES OC(CNC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC3=CNC4=CC=CC=C34)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H]5N(CCC5)C([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式 C91H127N25O23S ? XCF3COOH 分子量 1971.2
溶解度 Water: 1mg/ml 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.5073 mL 2.5365 mL 5.0731 mL
5 mM 0.1015 mL 0.5073 mL 1.0146 mL
10 mM 0.0507 mL 0.2537 mL 0.5073 mL
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