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Apatinib-d8 Sale

目录号 : GC49799

An internal standard for the quantification of apatinib

Apatinib-d8 Chemical Structure

Cas No.:2468771-43-7

规格 价格 库存 购买数量
1 mg
¥1,031.00
现货
5 mg
¥4,647.00
现货
10 mg
¥7,740.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Apatinib-d8 is intended for use as an internal standard for the quantification of apatinib by GC- or LC-MS. Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2; IC50 = 1 nM).1 It is less effective against c-Kit (IC50 = 429 nM), RET (IC50 = 13 nM), and c-Src (IC50 = 53 nM) and does not inhibit EGFR, HER2, or FGFR1 (IC50s = >10 µM).1 Apatinib has been shown to inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) stimulated by fetal bovine serum and, either alone or in combination with chemotherapeutic agents, prevents the growth of several established human tumor xenograft models.1

1.Tian, S., Quan, H., Xie, C., et al.YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivoCancer Sci.102(7)1374-1380(2011)

Chemical Properties

Cas No. 2468771-43-7 SDF Download SDF
Canonical SMILES O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC=C(C4(C#N)C([2H])([2H])C([2H])([2H])C([2H])([2H])C4([2H])[2H])C=C3
分子式 C24H15D8N5O 分子量 405.5
溶解度 DMSO: soluble 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4661 mL 12.3305 mL 24.6609 mL
5 mM 0.4932 mL 2.4661 mL 4.9322 mL
10 mM 0.2466 mL 1.233 mL 2.4661 mL
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