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Anisodamine 目录号 GC17736

weak antagonist of α1-adrenoceptors

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250mg
¥452.00
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500mg
¥525.00
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1g
¥861.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 55869-99-3 SDF
别名 6-hydroxy Hyoscyamine
化学名 αS-​(hydroxymethyl)​-​benzeneacetic acid, (1R,​3S,​5R,​6S)​-​6-​hydroxy-​8-​methyl-​8-​azabicyclo[3.2.1]​oct-​3-​yl ester
Canonical SMILES O=C([C@H](CO)C1=CC=CC=C1)O[C@@H]2C[C@@H](N3C)[C@@H](O)C[C@@H]3C2
分子式 C17H23NO4 分子量 305.4
溶解度 25mg/mL in ethanol or DMF, 20mg/mL in DMSO, 13.65mg/mL in H2O 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Anisodamine is a natural tropane alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively.[1] Anisodamine also has antioxidant effects that may protect against free radical-induced cellular damage.[2] Anisodamine is predominantly found in the roots of A. tanguticus, which is used in traditional Chinese medicine for topical applications.[3]

Reference:
[1]. Varma, D.R., and Yue, T.L. Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats. British Journal of Pharmacology 87(3), 587-594 (1986).
[2]. Poupko, J.M., Baskin, S.I., and Moore, E. The pharmacological properties of anisodamine. Journal of Applied Toxicology 27(2), 116-121 (2007).
[3]. Ma, L., Gu, R., Tang, L., et al. Important poisonous plants in tβ ethnomedicine. Toxins (Basel) 7(1), 138-155 (2015).