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AN3365 (hydrochloride) Sale

(Synonyms: 3-[[(3S)-3-(氨基甲基)-1,3-二氢-1-羟基-2,1-苯并氧杂硼戊环-7-基]氧基]-1-丙醇盐酸盐,Epetraborole,GSK2251052) 目录号 : GC12345

A LeuRS inhibitor

AN3365 (hydrochloride) Chemical Structure

Cas No.:1234563-16-6

规格 价格 库存 购买数量
10mM (in 1mL Water)
¥1,838.00
现货
5mg
¥1,260.00
现货
10mg
¥2,070.00
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25mg
¥4,590.00
现货
50mg
¥7,380.00
现货
100mg
¥11,880.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].

The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. The leucyl-tRNA synthetase has been involved in catalyzing the ATP-dependent ligation of L-leucine to tRNA. It has been found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain [2].

AN3365 potently and selectively inhibited bacterial leucyl-tRNA synthetase activity against Gram-negative bacteria. AN3365 was a member of a novel class of boron-containing compounds, the aminomethyl benzoxoaboroles, which showed potential to combat multidrug resistance. AN3365 was active against many microbial strains, including strains of Enterobacteriaceae with the MIC50/90 of 0.5/1 μg/ml. AN3365 showed activity against the non-fermentative Gram-negative clinical isolates P. aeruginosa, A. baumannii, S. maltophilia, and B. cepacid with the MIC50/90s of 4/8, 4/8, 2/4, and 8/32 μg/ml, respectively [1].

References:
[1] Hernandez V, Crépin T, Palencia A, et al.  Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria[J]. Antimicrobial agents and chemotherapy, 2013, 57(3): 1394-1403.
[2] Rouget P, Chapeville F.  Leucyl‐tRNA Synthetase[J]. European journal of biochemistry, 1971, 23(3): 443-451.

Chemical Properties

Cas No. 1234563-16-6 SDF
别名 3-[[(3S)-3-(氨基甲基)-1,3-二氢-1-羟基-2,1-苯并氧杂硼戊环-7-基]氧基]-1-丙醇盐酸盐,Epetraborole,GSK2251052
化学名 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol, monohydrochloride
Canonical SMILES OB1O[C@H](CN)C2=CC=CC(OCCCO)=C21.Cl
分子式 C11H16BNO4 • HCl 分子量 273.5
溶解度 ≤10mg/ml in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.6563 mL 18.2815 mL 36.5631 mL
5 mM 0.7313 mL 3.6563 mL 7.3126 mL
10 mM 0.3656 mL 1.8282 mL 3.6563 mL
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