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AKT Kinase Inhibitor

目录号 GC16366

AKT Kinase Inhibitor

规格 价格 库存 购买数量
10mM * 1mL in DMSO
¥3,465.00
现货
5mg
¥3,150.00
现货
10mg
¥5,400.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

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产品描述

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

References:
[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

Chemical Properties

Cas No. 842148-40-7 SDF
别名 N/A
化学名 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]prop-2-yn-1-ol
Canonical SMILES CCN1C2=C(C(=NC=C2OCCCN)C#CCO)N=C1C3=NON=C3N
分子式 C16H19N7O3 分子量 357.37
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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