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Adapalene sodium salt Sale

(Synonyms: 阿达帕林钠; CD 271 sodium salt) 目录号 : GC14379

An RARβ and RARγ agonist

Adapalene sodium salt Chemical Structure

Cas No.:911110-93-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥389.00
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50mg
¥378.00
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100mg
¥578.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Adapalene sodium salt(CD 271; Differin), a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).Target: Retinoic acid receptor agonist (RAR)Adapalene sodium salt is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. Adapalene sodium salt is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris [1].Thirty-six rats of either sex were divided into six groups (two control groups, and an etodolac, indomethacin, tretinoin and adapalene sodium salt group) of six animals each. Each group was given different drugs or chemicals. The inhibitory activities of the drugs were determined on carrageenan-induced rat-paw oedema. The inhibition rate (53.48%) in the tretinoin group was found to be higher than adapalene sodium salt and controls (P < 0.05). Adapalene sodium salt was found to have an inhibition rate of 10.28%, and when compared with the other groups, was found to have no statistically significant anti-inflammatory activity [2].Clinical indications: Acne; Purpura; SunburnFDA Approved Date: 1996Toxicity: Skin redness; dryness; itching; scaling; mild burning

References:
[1]. Ellis CN, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel in the topical treatment of acne vulgaris. Br J Dermatol. 1998 Oct;139 Suppl 52:41-7.
[2]. Akdeniz N, et al. Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats. Clin Exp Dermatol. 2005 Sep;30(5):570-2.

Chemical Properties

Cas No. 911110-93-5 SDF
别名 阿达帕林钠; CD 271 sodium salt
化学名 sodium 6-(3-((3r,5r,7r)-adamantan-1-yl)-4-methoxyphenyl)-2-naphthoate
Canonical SMILES COC1=C(C23C[C@@]4([H])C[C@](C2)([H])C[C@](C3)([H])C4)C=C(C5=CC=C6C=C(C([O-])=O)C=CC6=C5)C=C1.[Na+]
分子式 C28H27NaO3 分子量 434.5
溶解度 ≥ 4.35mg/mL in DMSO with gentle warming 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.3015 mL 11.5075 mL 23.015 mL
5 mM 0.4603 mL 2.3015 mL 4.603 mL
10 mM 0.2301 mL 1.1507 mL 2.3015 mL
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