γ-Glu-Phe (trifluoroacetate salt)
(Synonyms: γ-Glutamylphenylalanine) 目录号 : GC52404A dipeptide with metabolism-altering activity
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
γ-Glu-Phe is an endogenous dipeptide that is composed of L-glutamic acid and L-phenylalanine and has also been found in Allium.1 It prevents increases in lipid accumulation in AML12 hepatocytes stimulated with oleic acid when used at a concentration of 30 µM. γ-Glu-Phe (2.5-10 mM) increases levels of the calcium-sensing receptor (CaSR) and secretion of cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) in STC-1 enteroendocrine cells.2 Changes in urine levels of γ-Glu-Phe are associated with hypertension and phenylketonuria (PKU) and changes in serum levels are associated with prostate cancer.3,4,5
1.Lee, Y.G., Cho, J.-Y., Hwang, E.J., et al.Glu-Phe from onion (Allium Cepa L.) attenuates lipogenesis in hepatocytesBiosci. Biotech. Biochem.81(7)1409-1416(2017) 2.Yang, J., Bai, W., Zeng, X., et al.γ-[Glu](n=1,2)-Phe/-Met/-Val stimulates gastrointestinal hormone (CCK and GLP-1) secretion by activating the calcium-sensing receptorFood Funct.10(7)4071-4080(2019) 3.Shi, M., He, J., Li, C., et al.Metabolomics study of blood pressure salt-sensitivity and hypertensionNutr. Metab. Cardiovasc. Dis.32(7)1681-1692(2022) 4.Peck, H., and Pollitt, R.J.The occurrence of γ-glutamylphenylalanine in the urine of newborn phenylketonuricsClin. Chim. Acta94(3)237-240(1979) 5.Huang, J., Mondul, A.M., Weinstein, S.J., et al.Serum metabolomic profiling of prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trialBr. J. Cancer115(9)1087-1095(2016)
| Cas No. | SDF | Download SDF | |
| 别名 | γ-Glutamylphenylalanine | ||
| Canonical SMILES | OC([C@@H](NC(CC[C@H](N)C(O)=O)=O)CC1=CC=CC=C1)=O.OC(C(F)(F)F)=O | ||
| 分子式 | C14H18N2O5 ? XCF3COOH | 分子量 | 294.3 |
| 溶解度 | DMF: 2 mg/ml,DMSO: 3 mg/ml,PBS (pH 7.2): 10 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3979 mL | 16.9895 mL | 33.9789 mL |
| 5 mM | 0.6796 mL | 3.3979 mL | 6.7958 mL |
| 10 mM | 0.3398 mL | 1.6989 mL | 3.3979 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。