γ-D-Glutamylglycine (trifluoroacetate salt)
(Synonyms: γ-DGG) 目录号 : GC49865
An excitatory amino acid antagonist
Cas No.:71822-19-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
γ-D-Glutamylglycine (γ-DGG) is an antagonist of the excitatory amino acids NMDA , quisqualate, kainate, and glutamate.1 It decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat hippocampal slices when used at a concentration of 200 mM. Subdural administration of γ-DGG inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC50s = 63, 9.5, and 31 µM, respectively).2 γ-DGG reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED50s = 0.058, 0.046, and 0.054 µmol, i.c.v., respectively).3
1.Crunelli, S., Forda, S., and Kelly, J.S.Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrusJ. Physiol.341627-640(1983) 2.Raigorodsky, G., and Urca, G.Spinal antinociceptive effects of excitatory amino acid antagonists: Quisqualate modulates the action of N-methyl-D-aspartateEur. J. Pharmacol.182(1)37-47(1990) 3.Croucher, M.J., Collins, J.F., and Meldrum, B.S.Anticonvulsant action of excitatory amino acid antagonistsScience216(4548)899-901(1982)
| Cas No. | 71822-19-0 | SDF | Download SDF |
| 别名 | γ-DGG | ||
| Canonical SMILES | OC(CNC(CC[C@@H](N)C(O)=O)=O)=O.FC(F)(C(O)=O)F | ||
| 分子式 | C7H12N2O5 • CF3COOH | 分子量 | 318.2 |
| 溶解度 | Water: soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1427 mL | 15.7134 mL | 31.4268 mL |
| 5 mM | 0.6285 mL | 3.1427 mL | 6.2854 mL |
| 10 mM | 0.3143 mL | 1.5713 mL | 3.1427 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。