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8-Nitroguanine Sale

目录号 : GC18426

A mutagenic nitrative guanine derivative

8-Nitroguanine Chemical Structure

Cas No.:168701-80-2

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1mg
¥1,697.00
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5mg
¥6,789.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents. It is mutagenic and induces G:C to T:A transversion in DNA. Incorporation of 8-nitroguanine as an 8-nitroG:anti-G base pair into a primer template stalls human DNA polymerase β and induces a 2:1 preference for deoxyadenosine (dA) insertion over deoxycytosine (dC). 8-Nitroguanine levels are increased in the lung tissue of mice with conditional expression of mutant K-Ras(G12V) that developed lung adenocarcinoma and in the lung tissue and peripheral lymphocyte DNA of cigarette smoke-exposed rats. It is also increased in the lung tissue of influenza- or Sendai virus-infected mice and the colon epithelial cells of mice in an inflammatory bowel disease (IBD) model.

Chemical Properties

Cas No. 168701-80-2 SDF
化学名 2-amino-1,9-dihydro-8-nitro-6H-purin-6-one
Canonical SMILES O=C1C2=C(N=C([N+]([O-])=O)N2)N=C(N)N1
分子式 C5H4N6O3 分子量 196.1
溶解度 1 M NaOH: 50 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.0994 mL 25.4972 mL 50.9944 mL
5 mM 1.0199 mL 5.0994 mL 10.1989 mL
10 mM 0.5099 mL 2.5497 mL 5.0994 mL
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