5-OMe-UTP,100mM Sodium Solution
目录号 : GB20004
5-OMe-UTP是一种甲氧基修饰的UTP类似物,常用于在体外mRNA合成过程中替代天然存在的UTP。
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
-
Purity: ≥98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
5-Methoxyuridine-5'-Triphosphate (5-OMe-UTP) is a methoxy-modified UTP analogue of naturally occurring uridine triphosphate (UTP) [1]. 5-OMe-UTP is also a common chemical modification used in in vitro mRNA synthesis for incorporation into messenger RNA (mRNA) using T7 RNA polymerase, thereby reducing the activity and immunogenicity of the resulting mRNA[2].
References:
[1]. Denzil Furtado, Christina Cortez-Jugo, et al. "mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts." Mol Pharm. PMID: 36125338
[2]. Li, Bin; Zeng, Chunxi; Dong, Yizhou . Design and assessment of engineered CRISPR-Cpf1 and its use for genome editing.
5-Methoxyuridine-5'-Triphosphate (5-OMe-UTP)是一种甲氧基修饰的UTP,是天然存在的三磷酸尿苷(UTP)的类似物[1]。5-OMe-UTP也是一种用于体外mRNA合成的常见化学修饰,用于使用T7 RNA聚合酶掺入信使RNA(mRNA)中,从而降低所得mRNA的活性以及免疫原性[2]。
| Cas No. | SDF | ||
| 分子式 | C10H14N2Na3O16P3 | 分子量 | 580.11 |
| 溶解度 | 储存条件 | Store at -20°C or below, always avoid freeze-thaw cycles. | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7238 mL | 8.6191 mL | 17.2381 mL |
| 5 mM | 0.3448 mL | 1.7238 mL | 3.4476 mL |
| 10 mM | 0.1724 mL | 0.8619 mL | 1.7238 mL |