3-deoxy Glucosone
(Synonyms: 3-脱氧葡萄糖醛酮,2-keto-3-Deoxyglucose) 目录号 : GC40744A precursor for advanced glycation endproducts
Cas No.:4084-27-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes.[1] [2]I[3] t is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies.[4] 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.
Reference:
[1]. Yamada, H., Miyata, S., Igaki, N., et al. Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction. The Journal of Biological Chemisty 269(32), 20275-20280 (1994).
[2]. Kusunoki, H., Miyata, S., Ohara, T., et al. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. Diabetes Care 26(6), 1889-1894 (2003).
[3]. Niwa, T., and Tsukushi, S. 3-Deoxyglucosone and AGEs in uremic complications: Inactivation of glutathione peroxidase by 3-deoxyglucosone. Kidney Int.Suppl. 78, S37-S41 (2001).
[4]. Thornalley, P.J., Langborg, A., and Minhas, H.S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochemistry Journal 344(Pt 1), 109-116 (1999).
| Cas No. | 4084-27-9 | SDF | |
| 别名 | 3-脱氧葡萄糖醛酮,2-keto-3-Deoxyglucose | ||
| 化学名 | 3-deoxy-D-erythro-hexos-2-ulose | ||
| Canonical SMILES | OC[C@@H](O)[C@@H](O)CC(C=O)=O | ||
| 分子式 | C6H10O5 | 分子量 | 162.1 |
| 溶解度 | 1mg/mL in ethanol, 20mg/mL in DMSO, or in DMF | 储存条件 | Store at -20°C,protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.169 mL | 30.8452 mL | 61.6903 mL |
| 5 mM | 1.2338 mL | 6.169 mL | 12.3381 mL |
| 10 mM | 0.6169 mL | 3.0845 mL | 6.169 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。