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24, 25-Dihydroxy VD3 Sale

(Synonyms: 24,25-二羟基维生素 D3) 目录号 : GC17566

24, 25-二羟基VD3是一种与1,25-二羟基维生素D3密切相关的化合物,是维生素D3的活性形式。

24, 25-Dihydroxy VD3 Chemical Structure

Cas No.:40013-87-4

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产品描述

24, 25-dihydroxyvitamin D3 [24,25(OH)2D3] is a Vitamin D (VD [1]) analogue that can inhibit some metabolic processes. It dose-dependently inhibited the intracellular 10-mM-Ca2+-evoked Ca2+-concentration-increase in enterocytes with an EC50 of 4.9 nM [2].

Vitamin D is important in calcium homeostasis, skeleton maintenance, and skeleton development. Two successive reactions are involved in the formation of VD: first the formation of 25-hydroxyvitamin D (25OHD); and second the formation of 1α, 25-dihydroxyvitamin D [1, 25(OH) 2D], the active hormonal vitamin D [3].

Ca2+ at 10 mM typically increased [Ca2+]i to a new stable value of 264 ± 16 nM from the basal value of 203 ± 13 nM. 24R, 25(OH)2D3 at concentrations from 0.2 pM to 202 nM dose-dependently inhibited the initial [Ca2+]i increase during the first 18 s (t= 300 to 318 s) and the final [Ca2+]i increase (t= 550 to 600 s), with EC50 values of 4.9 nM and 30 nM, respectively. 24R, 25(OH)2D3 at a concentration of 20 nM obtained the maximal inhibition (approximately 60%) to the Ca2+ uptake [2].

In adult female mongrel dogs with renal insufficiency, 24,25(OH)2D3 significantly decreased ionized calcium compared with the CK, without any changes in detected total calcium. This decrease was evident during the 2nd week. 24,25-(OH)2D3 treatment for an additional 4 weeks resulted in a very small additional decrease in the ionized calcium. 24,25(OH)2D3 made calcium balance in dogs slightly positive, while the calcium balance in the CK dogs was slightly negative [4].

References:
[1].  Dennis Wagner, Heather E. Hanwell, Kareena Schnabl, et al. The ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 is predictive of 25-hydroxyvitamin D3 response to vitamin D3 supplementation. Journal of Steroid Biochemistry & Molecular Biology, 2011, 126:72-77.
[2].  D Larsson, L Aksnes, B Th Björnsson, et al. Antagonistic effects of 24R,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 on L-type Ca2+ channels and Na+/Ca2+ exchange in enterocytes from Atlantic cod (Gadus morhua). Journal of Molecular Endocrinology, 2002, 28:53-68.
[3].  Thomas Edouard, Abdallah Husseini, Francis H. Glorieux, et al. Serum 24,25-Dihydroxyvitamin D Concentrations in Osteogenesis Imperfecta: Relationship to Bone Parameters. J. Clin. Endocrinol. Metab., 2012, 97(4):0000-0000.
[4].  Janet M. Canterbury, George Gavellas, Jacques J. Bourgoignie, et al. Metabolic Consequences of Oral Administration of 24,25-Dihydroxycholecalciferol to Uremic Dogs. J. Clin. Invest., 1980, 65(3):571-576.

Chemical Properties

Cas No. 40013-87-4 SDF
别名 24,25-二羟基维生素 D3
化学名 (6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol
Canonical SMILES CC(CCC(C(C)(C)O)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
分子式 C27H44O3 分子量 416.64
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.4002 mL 12.0008 mL 24.0015 mL
5 mM 0.48 mL 2.4002 mL 4.8003 mL
10 mM 0.24 mL 1.2001 mL 2.4002 mL
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