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20-ethyl Prostaglandin F2α Sale

(Synonyms: ICI 74205, 20ethyl PGF2α) 目录号 : GC41246

An analog of PGF with an extended ω-chain

20-ethyl Prostaglandin F2α Chemical Structure

Cas No.:36950-85-3

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1mg
¥873.00
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5mg
¥3,941.00
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10mg
¥6,990.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone. Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2α retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2α increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2α (50 nM). In vivo effects may be prolonged using 20-ethyl PGF2α, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2α as a substrate is only 35% of the activity observed with PGF2α.

Chemical Properties

Cas No. 36950-85-3 SDF
别名 ICI 74205, 20ethyl PGF2α
Canonical SMILES O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCCCC
分子式 C22H38O5 分子量 382.5
溶解度 DMF: 33 mg/ml,DMSO: 14 mg/ml,Ethanol: 33 mg/ml,PBS (pH 7.2): 3 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6144 mL 13.0719 mL 26.1438 mL
5 mM 0.5229 mL 2.6144 mL 5.2288 mL
10 mM 0.2614 mL 1.3072 mL 2.6144 mL
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