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2-fluoro Palmitic Acid

(Synonyms: 2-氟十六酸) 目录号 : GC17218

Inhibitor of sphingosine biosynthesis and long-chain acyl-CoA synthetase

2-fluoro Palmitic Acid Chemical Structure

Cas No.:16518-94-8

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5mg
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10mg
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25mg
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50mg
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产品描述

2-fluoropalmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase [1]. The length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-CoA synthetases (ACS).

Mammalian long-chain acyl-CoA synthetases (ACSL) activate fatty acids with chain lengths of 12 to 20 carbon atoms. The long-chain acyl-CoA synthetase mRNA is expressed virtually in heart, liver, and epididymal adipose tissues and, to a much lesser extent, in brain, small intestine, and lung [2].

Palmitic acid was a selective cytotoxic substance extracted from the marine algal. At concentrations ranging from 12.5 to 50 μg/ml, palmitic acid showed selective cytotoxicity to human leukemic cells, but no cytotoxicity to normal HDF cells. Palmitic acid (50 μg/ml) induced apoptosis in the human leukemic cell line MOLT-4. Palmitic acid also showed in vivo antitumor activity in mice [3]. 2-fluoropalmitic acid showed an inhibitory effect on sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC50 value of 0.2 mM [1].

References:
[1] Soltysiak R M, Matsuura F, Bloomer D, et al.  d, l-α-fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells[J]. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism, 1984, 792(2): 214-226.
[2] Suzuki H, Kawarabayasi Y, Kondo J, et al.  Structure and regulation of rat long-chain acyl-CoA synthetase[J]. Journal of Biological Chemistry, 1990, 265(15): 8681-8685.
[3] Harada H, Yamashita U, Kurihara H, et al.  Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga[J]. Anticancer research, 2001, 22(5): 2587-2590.

Chemical Properties

Cas No. 16518-94-8 SDF
别名 2-氟十六酸
化学名 2-fluorohexadecanoic acid
Canonical SMILES CCCCCCCCCCCCCCC(F)C(=O)O
分子式 C16H31FO2 分子量 274.4
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.6443 mL 18.2216 mL 36.4431 mL
5 mM 0.7289 mL 3.6443 mL 7.2886 mL
10 mM 0.3644 mL 1.8222 mL 3.6443 mL
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