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17-ODYA Sale

(Synonyms: 17-十八炔酸,Alk-16) 目录号 : GC12757

A fatty acid alkyne and palmitoylation probe

17-ODYA Chemical Structure

Cas No.:34450-18-5

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Sample solution is provided at 25 µL, 10mM.

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产品描述

17-ODYA is a potent inhibitor of cytochrome P450 fatty acid ω-hydroxylase [1].

ω-hydroxylase is a member of the cytochrome P450 superfamily of enzymes, which are monooxygenases that involved in synthesis of steroids, cholesterol and other lipids. ω-hydroxylase inactivates and degrades leukotriene B4, a potent mediator of inflammation.

In isolated single cells derived from rat portal vein, 17-ODYA (5 μM) inhibited delayed rectifier current (IK(V)) but didn’t influence A-type current (IK(A)). Also, 17-ODYA (5 μM) increased current flow through Ca-sensitive K-channel (BKCa) [2].

In renal cortical microsomes of rats, 17-ODYA inhibited the formation of epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid and dihydroxyeicosatrienoic acids with IC50 value < 100 nM. 17-ODYA inhibited the omega-hydroxylation of arachidonic acid by 61.3% and increased sodium excretion and urine flow [1]. In rabbit arteries with both endothelium-intact (E+) and endothelium-removal (E-), 17-ODYA increased the efficacy to angiotensin II. Also, 17-ODYA inhibited Ach-relaxation. 17-ODYA improved vasoconstrictor cyclooxygenase-2 metabolites release by inhibition of prostaglandin-ω-hydroxylase [3].

References:
[1].  Zou AP, Ma YH, Sui ZH, et al. Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. J Pharmacol Exp Ther, 1994, 268(1): 474-481.
[2].  Edwards G, Zygmunt PM, Högestätt ED, et al. Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein. Br J Pharmacol, 1996, 119(4): 691-701.
[3].  Jerez S, Sierra L, de Bruno MP. 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins. Prostaglandins Other Lipid Mediat, 2012, 97(1-2): 36-42.

Chemical Properties

Cas No. 34450-18-5 SDF
别名 17-十八炔酸,Alk-16
化学名 octadec-17-ynoic acid
Canonical SMILES OC(CCCCCCCCCCCCCCCC#C)=O
分子式 C18H32O2 分子量 280.45
溶解度 1 mg/mL in DMSO, 10mg/mL in DMF,10mg/mL in ethanol 储存条件 Store at -20°C
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1 mM 3.5657 mL 17.8285 mL 35.657 mL
5 mM 0.7131 mL 3.5657 mL 7.1314 mL
10 mM 0.3566 mL 1.7828 mL 3.5657 mL
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