1-Isothiocyanato-6-(methylsulfenyl)-hexane
(Synonyms: Lesquerellin, 6-Methylthiohexyl Isothiocyanate) 目录号 : GC49495
An isothiocyanate with diverse biological activities
Cas No.:4430-39-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1-Isothiocyanato-6-(methylsulfenyl)-hexane is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.1,2 It is active against the bacterium B. subtilis in an agar diffusion assay when used at a concentration of 25 µmol/disc and the fungus T. mentagrophytes (MIC = 25 µg/ml).2 It has repellent activity in the blue mussel (M. edulis) assay, as well as antifouling activity in the conventional submerged assay when applied to polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm2.2
1.Toh, H., Nishimura, A., Takasawa, R., et al.ω-Methylsulfinylalkyl isothiocyanates in wasabi, Wasabia japonica MatsumAgric. Biol. Chem.54(6)1587-1589(1990) 2.Takasawa, R., Ogura, C., Watanabe, N., et al.An efficient laboratory matching and screening method for antifouling substances using the blue mussel, Mytilus edulis, and an antimicrobial assayBiosci. Biotech. Bioch.56(8)1208-1211(1992)
| Cas No. | 4430-39-1 | SDF | Download SDF |
| 别名 | Lesquerellin, 6-Methylthiohexyl Isothiocyanate | ||
| Canonical SMILES | CSCCCCCCN=C=S | ||
| 分子式 | C8H15NS2 | 分子量 | 189.3 |
| 溶解度 | Ethanol: 10 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.2826 mL | 26.4131 mL | 52.8262 mL |
| 5 mM | 1.0565 mL | 5.2826 mL | 10.5652 mL |
| 10 mM | 0.5283 mL | 2.6413 mL | 5.2826 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Anti-Cancer Effects of Oxygen-Atom-Modified Derivatives of Wasabi Components on Human Leukemia Cells
Int J Mol Sci 2023 Apr 6;24(7):6823.PMID:37047794DOI:PMC10095376
1-Isothiocyanato-6-(methylsulfinyl)-hexanate (6-MITC) is a natural compound found in Wasabia japonica. The synthetic derivatives 1-Isothiocyanato-6-(methylsulfenyl)-hexane (I7447) and 1-Isothiocyanato-6-(methylsulfonyl)-hexane (I7557) were obtained from 6-MITC by deleting and adding an oxygen atom to the sulfone group, respectively. We previously demonstrated that extensive mitotic arrest, spindle multipolarity, and cytoplasmic vacuole accumulation were induced by 6-MITC and inhibited the viability of human chronic myelogenous leukemia K562 cells. In this study, we examined the anti-cancer effects of 6-MITC derivatives on human chronic myelogenous leukemia (CML) cells. Autophagy was identified as the formation of autophagosomes with double-layered membranes using transmission electron microscopy. Cell cycle and differentiation were analyzed using flow cytometry. Apoptosis was detected by annexin V staining. After treatment with I7447 and I7557, the G2/M phase of cell cycle arrest was revealed. Cell death can be induced by a distinct mechanism (the simultaneous occurrence of autophagy and aberrant mitosis). The expression levels of acridine orange were significantly affected by lysosomal inhibitors. The natural wasabi component, 6-MITC, and its synthetic derivatives have similar effects on human chronic myelogenous leukemia cells and may be developed as novel therapeutic agents against leukemia.