1-Carboxycyclohexaneacetic Acid |
| 目录号 GC49861 |
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
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Purity: >95.00%
- COA (Certificate Of Analysis)
- Datasheet
1-Carboxycyclohexaneacetic acid is a potential impurity in commercial preparations of the antiepileptic gabapentin.1 It has also been used as a precursor in the synthesis of antagonists of the serotonin (5-HT) receptor subtype 5-HT2A.2
1.Ragham, P.K., and Chandrasekhar, K.B.Development and validation of a stability-indicating RP-HPL C-CAD method for gabapentin and its related impurities in presence of degradation productsJ. Pharm. Biomed. Anal.125122-129(2016) 2.Obniska, J., Pawlowski, M., Kolaczkowski, M., et al.Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dionePol. J. Pharmacol.55(4)553-557(2003)
| Cas No. | 67950-95-2 | SDF | Download SDF |
| 别名 | N/A | ||
| 化学名 | N/A | ||
| Canonical SMILES | O=C(CC1(CCCCC1)C(O)=O)O | ||
| 分子式 | C9H14O4 | 分子量 | 186.2 |
| 溶解度 | DMF: 20 mg/mL,DMSO: 33 mg/mL,Ethanol: 25 mg/mL,PBS (pH 7.2): 0.16 mg/mL | 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % ddH2O | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。