1-Benzylimidazole
(Synonyms: N-苄基咪唑) 目录号 : GC17678
A selective inhibitor of TXA synthase
Cas No.:4238-71-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Benzylimidazole is a selective inhibitor of thromboxane synthase and a stimulator of UDP-glucuronosyltransferase [1,2].
Thromboxane synthase is a cytochrome P450 enzyme. The cytochrome P450 proteins have been involved in catalyzing many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The enzyme plays an important role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants [3].
1-Benzylimidazole selectively inhibited the activity of thromboxane synthase. 1-Benzylimidazole reduced TXB2 levels and increased blood flow in ischemia-reperfusion injury of rat brain [1]. In male Wistar rats, gastrically administration of 1-benzylimidazole (25, 75 and 100 mg/kg/day) caused a dose-dependent hepatomegaly. 1-Benzylimidazole decreased the plasma level in triglycerides by 60–70%. 1-benzylimidazole stimulated three distinct forms of UDP-glucuronosyltransferase. 1-benzylimidazole significantly increased the activities towards 4-methylumbelliierone, 1-naphthol, morphine or a monoterpenoid alcohol, nopol [2]. Benzylimidazole increased hepatocellular CYP1A catalytic activity and CYP1A mRNA in a concentration-dependent way [4].
References:
[1] Pettigrew L C, Grotta J C, Rhoades H M, et al. Effect of thromboxane synthase inhibition on eicosanoid levels and blood flow in ischemic rat brain[J]. Stroke, 1989, 20(5): 627-632
[2]. Magdalou J, Totis M, Boiteux-Antoine A F, et al. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver[J]. Biochemical pharmacology, 1988, 37(17): 3297-3304.
Shen R F, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science, 1998, 5(3): 153-172.
[3] Shen R F, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science, 1998, 5(3): 153-172.
[4] Navas J M, Chana A, Herradón B, et al. Induction of CYP1A by the N‐imidazole derivative, 1‐benzylimidazole[J]. Environmental toxicology and chemistry, 2003, 22(4): 830-836.
| Cas No. | 4238-71-5 | SDF | |
| 别名 | N-苄基咪唑 | ||
| 化学名 | 1-(phenylmethyl)-1H-imidazole | ||
| Canonical SMILES | c1ccc(cc1)Cn1cncc1 | ||
| 分子式 | C10H10N2 | 分子量 | 158.2 |
| 溶解度 | DMF: >530 µ g/ml,DMSO: >560 µ g/ml,Ethanol: >500 µ g/ml,PBS pH 7.2: >6.5 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.3211 mL | 31.6056 mL | 63.2111 mL |
| 5 mM | 1.2642 mL | 6.3211 mL | 12.6422 mL |
| 10 mM | 0.6321 mL | 3.1606 mL | 6.3211 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。