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Zinc Pyrithione Sale

(Synonyms: 吡啶硫酮锌) 目录号 : GC16453

A coordination complex of zinc and pyrithione

Zinc Pyrithione Chemical Structure

Cas No.:13463-41-7

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10mM (in 1mL DMSO)
¥420.00
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50mg
¥483.00
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产品描述

Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.Target: Proton PumpZinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM [1]. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential [2]. Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50) = 8.27 μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed [3].

References:
[1]. Ermolayeva, E. and D. Sanders, Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol, 1995. 61(9): p. 3385-90.
[2]. Xiong, Q., H. Sun, and M. Li, Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol, 2007. 3(5): p. 287-96.
[3]. Marcheselli, M., C. Rustichelli, and M. Mauri, Novel antifouling agent zinc pyrithione: determination, acute toxicity, and bioaccumulation in marine mussels (Mytilus galloprovincialis). Environ Toxicol Chem, 2010. 29(11): p. 2583-92.

Chemical Properties

Cas No. 13463-41-7 SDF
别名 吡啶硫酮锌
化学名 zinc;1-oxidopyridine-2-thione
Canonical SMILES C1=CC(=S)N(C=C1)[O-].C1=CC(=S)N(C=C1)[O-].[Zn+2]
分子式 C10H8N2O2S2Zn 分子量 317.7
溶解度 ≥ 13.45mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mM 3.1476 mL 15.7381 mL 31.4762 mL
5 mM 0.6295 mL 3.1476 mL 6.2952 mL
10 mM 0.3148 mL 1.5738 mL 3.1476 mL
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