Zilpaterol
(Synonyms: 齐帕特罗,RU-42173,Zilmax?) 目录号 : GC13333β-adrenergic receptor agonist
Cas No.:119520-05-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
Zilpaterol is a β-adrenergic receptor agonist.
β-adrenergic receptors, prototypic G-protein-coupled receptors, play a key role in regulating numerous physiological processes.
In vitro: Previus study found that there was no effect of zilpaterol (ZH) on thymidine incorporation into DNA. ZH at 1 μM could decrease β1-AR mRNA, and 0.01 and 1 μM ZH decreased β2-AR and β3-AR mRNA in myoblasts. There was no effect of ZH on the β-AR or IGF-I gene expression in fused myotube cultures. The β2-AR antagonist ICI-118, 551 attenuated the effect of ZH to reduce expression of β1- and β2-AR mRNA. There was no effect of ICI-118, 551 or ZH on β3-AR or IGF-I. In addition, the total lipid synthesis from acetate was increased by ZH in bovine subcutaneous adipose tissue explants in the absence of theophylline [1].
In vivo: FDA has approved label claims of increased rate of BW gain, improved feed efficiency, and increased carcass leanness. The feeding of ZH for 20 to 40 d with a 3-d withdrawal resulted in significantly increased ADG. Such increases equate to an average of 9 kg heavier BW in ZH-fed steers. Moreover, hot carcass weight has been shown to increase to a larger degree compared with BW, with an average improvement of 15 kg [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Miller, E. K.,Chung, K.Y.,Hutcheson, J.P., et al. Zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. Journal of Animal Science 90(4), 1317-1327 (2012).
[2] Delmore, R. J.,Hodgen, J.M. and Johnson, B.J. Perspectives on the application of zilpaterol hydrochloride in the United States beef industry. Journal of Animal Science 88(8), 2825-2828 (2010).
| Cas No. | 119520-05-7 | SDF | |
| 别名 | 齐帕特罗,RU-42173,Zilmax? | ||
| 化学名 | (6R,7R)-rel-4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]-imidazo[4,5,1-jk][1]benzazepin-2(1H)-one | ||
| Canonical SMILES | O=C1NC2=CC=CC3=C2N1CC[C@H](NC(C)C)[C@H]3O | ||
| 分子式 | C14H19N3O2 | 分子量 | 261.3 |
| 溶解度 | ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.827 mL | 19.1351 mL | 38.2702 mL |
| 5 mM | 0.7654 mL | 3.827 mL | 7.654 mL |
| 10 mM | 0.3827 mL | 1.9135 mL | 3.827 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。