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UVI 3003 Sale

目录号 : GC13199

A pan-RXR antagonist

UVI 3003 Chemical Structure

Cas No.:847239-17-2

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50mg
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10mg
¥1,260.00
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Sample solution is provided at 25 µL, 10mM.

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实验参考方法

Cell experiment:

At ∼30-40% confluence cells are treated with vehicle (ethanol), all-trans retinoic acid (1 μM), the RAR inverse agonist BMS493 (10 μM), or the RXR antagonist UVI 3003 (10 μM) for 24 h in proliferation media with a final concentration of ethanol at 0.1% for all treatments. At the end of the 24-h treatment cell proliferation rates are assessed[2].

References:

[1]. Zhu J, et al. The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicol Appl Pharmacol. 2017 Jan 1;314:91-97.
[2]. Hebert SL, et al. Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res. 2017 Dec 1;361(1):101-111.

产品描述

UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.

UVI3003 inhibits the activity of xenopus and human RXRα, with IC50s of 0.22 and 0.24 μM, respectively. UVI3003 fully activates xPPARγ with an EC50 of 12.6 μM, and is almost completely inactive on hPPARγ and mPPARγ[1]. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression[2].

References:
[1]. Zhu J, et al. The unexpected teratogenicity of RXR antagonist UVI3003 via activation of PPARγ in Xenopus tropicalis. Toxicol Appl Pharmacol. 2017 Jan 1;314:91-97.
[2]. Hebert SL, et al. Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res. 2017 Dec 1;361(1):101-111.

Chemical Properties

Cas No. 847239-17-2 SDF
化学名 (Z)-3-(4-hydroxy-3-(5,5,8,8-tetramethyl-3-(pentyloxy)-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl)acrylic acid
Canonical SMILES OC1=CC=C(/C=C\C(O)=O)C=C1C(C=C2C(C)(C)CCC(C)(C)C2=C3)=C3OCCCCC
分子式 C28H36O4 分子量 436.58
溶解度 DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 20 mg/ml 储存条件 Store at -20°C
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1 mM 2.2905 mL 11.4527 mL 22.9053 mL
5 mM 0.4581 mL 2.2905 mL 4.5811 mL
10 mM 0.2291 mL 1.1453 mL 2.2905 mL
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