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Urotensin I TFA Sale

(Synonyms: Catostomus urotensin I TFA) 目录号 : GC61583

UrotensinI(CatostomusurotensinI)TFA是一种类CRF样肽,可作为CRF受体激动剂,在细胞实验中,对人CRF1,CRF2和大鼠CRF2α受体的pEC50值分别为11.46,9.36和9.85,对hCRF1,rCRF2α和mCRF2β受体的Ki值分别为0.4,1.8和5.7nM。

Urotensin I TFA Chemical Structure

规格 价格 库存 购买数量
500 μg
¥3,060.00
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产品描述

Urotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively[1][2].

Urotensin I is 2-3 times more potent than CRF or sauvagine in stimulating ACTH release from a superfused goldfish anterior pituitary cell column[3].Rat tail artery strips were incubated in the presence of 4 x 10(-3) M theophylline and Urotensin I (UI). At the concentrations of 1.50, 7.50 mU/ml but not of 0.75 mU/ml Urotensin I, the content of cAMP increased significantly[4].

Intraperitoneal injections of urotensin I, a CRF-like neuropeptide isolated from the caudal neurosecretory system of the teleost Catostomus commersoni, ovine CRF and sauvagine all produced significant increases in circulating levels of plasma cortisol in goldfish in which endogenous ACTH secretion was suppressed with betamethasone[3].

[1]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. [2]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. [3]. Fryer J, et al. Urotensin I, a CRF-like neuropeptide, stimulates acth release from the teleost pituitary. Endocrinology. 1983;113(6):2308-2310. [4]. Gerritsen ME, et al. Urotensin I effects on intracellular content of cyclic AMP in the rat tail artery. Eur J Pharmacol. 1979;60(2-3):211-220.

Chemical Properties

Cas No. SDF
别名 Catostomus urotensin I TFA
分子式 C212H341F3N62O69S2 分子量 4983.48
溶解度 储存条件 Store at -20°C
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1 mM 0.2007 mL 1.0033 mL 2.0066 mL
5 mM 0.0401 mL 0.2007 mL 0.4013 mL
10 mM 0.0201 mL 0.1003 mL 0.2007 mL
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