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U 73343 Sale

目录号 : GC17960

An inactive analog of U-73122

U 73343 Chemical Structure

Cas No.:142878-12-4

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1mg
¥261.00
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5mg
¥765.00
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10mg
¥1,275.00
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25mg
¥2,845.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

U-73122 is an inhibitor of PLC-dependent processes, however, the mechanism of action remains unclear.[1],[2],[3] The IC50 values for inhibition of platelet aggregation induced by collagen or thrombin are 0.6 and 5 µM, respectively.2 It also exhibits inhibitory activity against HIV-1 integrase with an IC50 value of 7 µM.[4] U-73343 is a close structural analog of U-73122 that does not inhibit PLC, making it useful as a negative control for PLC inhibition.[1]

Reference:
[1]. Smith, R.J., Sam, L.M., Justen, J.M., et al. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: Effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. Journal of Pharmacology and Experimental Therapeutics 253, 688-697 (1990).
[2]. Bleasdale, J.E., Thakur, N.R., Gremban, R.S., et al. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. Journal of Pharmacology and Experimental Therapeutics 255, 756-768 (1990).
[3]. Hildebrandt, J.P., Plant, T.D., and Meves, H. The effects of bradykinin on K+ currents in NG108-15 cells treated with U73122, a phospholipase C inhibitor, or neomycin. British Journal of Pharmacology 120, 841-850 (1997).
[4]. Burke, T.R., Jr., Fesen, M.R., Mazumder, A., et al. Hydroxylated aromatic inhibitors of HIV-1 integrase. Journal of Medicinal Chemistry 38, 4171-4178 (1995).

Chemical Properties

Cas No. 142878-12-4 SDF
化学名 1-(6-(((8R,9S,13S,14S,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)amino)hexyl)pyrrolidine-2,5-dione
Canonical SMILES C[C@]12CC[C@]3([H])C4=CC=C(OC)C=C4CC[C@@]3([H])[C@]1([H])CC[C@]2([H])NCCCCCCN5C(CCC5=O)=O
分子式 C29H42N2O3 分子量 466.66
溶解度 0.25mg/ml in ethanol; 0.5mg/ml in DMSO; 2mg/ml in DMF 储存条件 Store at -20°C
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1 mM 2.1429 mL 10.7144 mL 21.4289 mL
5 mM 0.4286 mL 2.1429 mL 4.2858 mL
10 mM 0.2143 mL 1.0714 mL 2.1429 mL
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