Triptorelin ([DTrp6]-LH-RH)
(Synonyms: 曲普瑞林) 目录号 : GC32772
Triptorelin是一个GnRH兴奋剂，能够抑制雌二醇引起的细胞增殖。
![Triptorelin ([DTrp6]-LH-RH) Chemical Structure](/media/struct/GC3/GC32772.png "Triptorelin ([DTrp6]-LH-RH) Chemical Structure")
Cas No.:57773-63-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferationIn vivo: (1) Triptorelin can improve the pregnancy rate by 12% to 15% in ewes6 and downregulate ovarian GnRHR-I expression of female rats, especially in late-growing follicles.(2) Triptorelin immunity blocked EET and UWT, inhibited uterine growth and development and enhance the expression levels s of ESR1, LHR, and FSHR proteins.
[1]. Wei S et al. Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR, and FSHR of mice. Immunopharmacol Immunotoxicol. 2016 Jun;38(3):197-204.
| Cas No. | 57773-63-4 | SDF | |
| 别名 | 曲普瑞林 | ||
| Canonical SMILES | Pyr-His-Trp-Ser-Tyr-{d-Trp}-Leu-Arg-Pro-Gly-NH2 | ||
| 分子式 | C64H82N18O13 | 分子量 | 1311.45 |
| 溶解度 | DMF: 10mg/mL,DMSO: 3mg/mL,PBS (pH 7.2): 3mg/mL | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.7625 mL | 3.8126 mL | 7.6251 mL |
| 5 mM | 0.1525 mL | 0.7625 mL | 1.525 mL |
| 10 mM | 0.0763 mL | 0.3813 mL | 0.7625 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Regression of the malignant aspects of intraepithelial neoplasias following an LH-RH agonist treatment and detection of human papillomavirus by molecular hybridization
Biomed Pharmacother 1989;43(3):183-5.PMID:2550098DOI:10.1016/0753-3322(89)90213-8.
Patients presenting genital intraepithelial neoplasia and/or flat condyloma were treated with DTrp6-LH-RH (Triptorelin) to induce a transitory suppression of estrogens. This treatment led in some cases to a complete clinical and histological regression accompanied by a disappearance of human papillomavirus sequences as detected by molecular hybridization.
[Systematic inhibition of the luteinizing hormone with a gonadoliberin analog, Triptorelin, during ovarian stimulation for fertilization in vitro. Choice of protocol]
Presse Med 1988 Apr 23;17(15):719-22.PMID:2968548doi
The quality of ovarian stimulation for in vitro fertilization with or without an LH-RH analogue was investigated in a randomized trial involving 30 women divided into 3 groups. Group I women were treated with the conventional clomiphene citrate-human menopausal gonadotropin combination without LH-RH analogue. Group II women (long regimen) received a slow-release preparation of Triptorelin (DTRp6-LH-RH), an LH-RH analogue, and human menopausal gonadotropin. Group II women (short regimen) were given Triptorelin with human menopausal gonadotropin. Inhibition of the endogenous luteinizing hormone using Triptorelin improved the results of in vitro fertilization in group II and group III women, but the short regimen was distinctly less compelling and less expensive than the long regimen.