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Triflupromazine hydrochloride Sale

(Synonyms: 盐酸三氟丙嗪) 目录号 : GC30790

A phenothiazine with diverse biological activities

Triflupromazine hydrochloride Chemical Structure

Cas No.:1098-60-8

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10mM (in 1mL DMSO)
¥491.00
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100mg
¥446.00
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产品描述

Triflupromazine is a phenothiazine with diverse biological activities.1,2,3,4 It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay).1 Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM).2 It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM.3 Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal.4 Formulations containing triflupromazine were previously used as antipsychotics.

1.Snyder, S.H., Greenberg, D., and Yamumura, H.I.Antischizophrenic drugs: Affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effectsJ. Psychiatr. Res.1191-95(1974) 2.Tuomisto, J.A new modification for studying 5-HT uptake by blood platelets: A re-evaluation of tricyclic antidepressants as uptake inhibitorsJ. Pharm. Pharmacol.26(2)92-100(1974) 3.De Castro, S.L., Soeiro, M.N., and De Meirelles Mde, N.Trypanosoma cruzi: Effect of phenothiazines on the parasite and its interaction with host cellsMem. Inst. Oswaldo Cruz87(2)209-215(1992) 4.Dastidar, S.G., Debnath, S., Mazumdar, K., et al.Triflupromazine: A microbicide non-antibiotic compoundActa Microbiol. Immuno. Hung.51(1-2)75-83(2004)

Chemical Properties

Cas No. 1098-60-8 SDF
别名 盐酸三氟丙嗪
Canonical SMILES FC(C(C=C1N2CCCN(C)C)=CC=C1SC3=C2C=CC=C3)(F)F.[H]Cl
分子式 C18H20ClF3N2S 分子量 388.88
溶解度 DMSO : ≥ 27 mg/mL (69.43 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 2.5715 mL 12.8574 mL 25.7149 mL
5 mM 0.5143 mL 2.5715 mL 5.143 mL
10 mM 0.2571 mL 1.2857 mL 2.5715 mL
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Research Update

TRIFLUPROMAZINE hydrochloride

Treatment of postalcoholic syndrome with triflupromazine hydrochloride

Comparative short-term evaluation of triflupromazine hydrochloride, chlorpromazine hydrochloride, and placebo in acutely disturbed patients

Triflupromazine Hydrochloride (Vesprin(R)) Its Value in Eye Surgery

Solubility and pKa determination of six structurally related phenothiazines

Solubilities of six structurally related phenothiazines, namely chlorpromazine hydrochloride, fluphenazine dihydrochloride, promazine hydrochloride, thioridazine hydrochloride, trifluoperazine dihydrochloride, and triflupromazine hydrochloride at constant pH were measured in the temperature range from 290 K to 350 K in three important drugs solvents: water, ethanol and 1-octanol using the dynamic method and UV-vis method. Dissociation constants and corresponding pK(a) values of drugs were obtained with Bates-Schwarzenbach method at temperature 298.15K in the buffer solutions. Our experimental pK(a) values for chlorpromazine hydrochloride, fluphenazine dihydrochloride, promazine hydrochloride, thioridazine hydrochloride, trifluoperazine dihydrochloride, and triflupromazine hydrochloride are 9.15, 10.01, 9.37, 8.89, 8.97, and 9.03, respectively. The basic thermal properties of pure drugs i.e. melting and solid-solid phase transition as well as glass-transition temperatures, the enthalpy of melting and phase transitions and the molar heat capacity at glass transition (at constant pressure) were measured with differential scanning microcalorimetry (DSC) technique. Molar volumes were calculated with Barton group contribution method. The experimental solubility data were correlated by means of three commonly known G(E) equations: the Wilson, NRTL and UNIQUAC with the assumption that the systems studied here have revealed simple eutectic mixtures. The root-mean-square deviations of temperature were used for the precision of the correlation. The activity coefficients of drugs at saturated solutions in each correlated binary mixture were calculated from the experimental data. These new data will help in all prediction-methods and their precision.