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Transdermal Peptide TFA Sale

目录号 : GC38869

Transdermal Peptide TFA (TD 1 peptide TFA) 是由 11 个氨基酸组成的多肽,可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合,主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide TFA 能够增强一些大分子在皮肤中的传递。

Transdermal Peptide TFA Chemical Structure

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1mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Transdermal Peptide TFA (TD 1 peptide TFA) is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide TFA can enhance the transdermal delivery of many macromolecules[1].

In the presence of Transdermal Peptide, because of the specific binding of Transdermal Peptide to ATP1B1, cells will upregulate the level of ATP1B1 to maintain function and structure; as a result, the expression of ATP1B1 increases. However, as time goes on, some Transdermal Peptide molecules may be transported into cells by endocytosis; consequently, the expression of ATP1B1 then decreases. The interaction between Transdermal Peptide and ATP1B1 changes not only the expression of ATP1B1, but also the localization of ATP1B1 and then the structure of the epidermal layer. This interaction can be attenuated by inhibitors or competitors, which would result in the reduced delivery of macromolecular drugs across the skin[1].

[1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67.

Chemical Properties

Cas No. SDF
分子式 C42H65F3N14O18S2 分子量 1175.17
溶解度 Water: 100 mg/mL (85.09 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.8509 mL 4.2547 mL 8.5094 mL
5 mM 0.1702 mL 0.8509 mL 1.7019 mL
10 mM 0.0851 mL 0.4255 mL 0.8509 mL
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