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Thienyldecyl Isothiocyanate Sale

目录号 : GC15244

An antiproliferative isothiocyanate

Thienyldecyl Isothiocyanate Chemical Structure

Cas No.:288323-41-1

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1mg
¥444.00
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5mg
¥1,951.00
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10mg
¥3,426.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Thienyldecyl isothiocyanate is a cytochrome P450 inhibitor [1].

The human cytochrome P450 (CYP), a cellular chromophore, has been implicated in metabolism of drugs, arachidonic acid, foreign chemicals, and eicosanoids; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; cholesterol metabolism and bile-acid biosynthesis; retinoic acid hydroxylation. Until now, there are more than 270 different CYP gene families have been identified, with 18 recorded in mammals. It has been repoted that cytochrome P450 is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes result in inborn errors of metabolism and contribute to many clinically relevant diseases [2].

Thienyldecyl isothiocyanate was an analog of thienylbutyl isothiocyanate. Thienyldecyl isothiocyanate showed antiproliferative activity against cancer cells presumably that, like many isothiocyanates. Thienyldecyl isothiocyanate functioned by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes [1].

References:
[1] Yu R, Mandlekar S, Harvey K J, et al.  Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity[J]. Cancer Research, 1998, 58(3): 402-408.
[2] Nebert D W, Russell D W.  Clinical importance of the cytochromes P450[J]. The Lancet, 2002, 360(9340): 1155-1162.

Chemical Properties

Cas No. 288323-41-1 SDF
化学名 2-(10-isothiocyanatodecyl)-thiophene
Canonical SMILES S=C=NCCCCCCCCCCC1=CC=CS1
分子式 C15H23NS2 分子量 281.5
溶解度 ≤30mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.5524 mL 17.762 mL 35.524 mL
5 mM 0.7105 mL 3.5524 mL 7.1048 mL
10 mM 0.3552 mL 1.7762 mL 3.5524 mL
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