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Tetrahydromagnolol Sale

(Synonyms: 二丙基联苯二醇,Magnolignan) 目录号 : GC15327

An agonist of CB1 and CB2 and antagonist of GPR55

Tetrahydromagnolol Chemical Structure

Cas No.:20601-85-8

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5mg
¥465.00
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10mg
¥881.00
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25mg
¥1,809.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Tetrahydromagnolol is a major metabolite of magnolol and acts as a peripheral CB2 receptor agonist. Tetrahydromagnolol also acts as an antagonist at GPR55 [1].

Cannabinoid (CB) receptors belong to the G protein-coupled receptor (GPCR) superfamily and are divided into CB1 and CB2. CB1 activation mediates analgesia, stimulation of appetite, and euphoria, among other effects. CB2 receptor activation results in analgesic and antiinflammatory effects. GPR55, a CB-related orphan receptor, is reported to interact with certain CBs [1].

Tetrahydromagnolol is a highly selective peripheral CB2 receptor agonist that is 19-fold more potent than magnolol with EC50 and Ki values of 0.17 μM and 0.42 μM, respectively. Magnolol is a bioactive compound isolated from the bark of Magnolia officinalis that is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. Magnolol behaved as a partial agonist with selectivity for the CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM). In β-arrestin translocation assay, Tetrahydromagnolol inhibited LPI-induced GPR55 activation with KB value of 13.3 μM [1].

Reference:
[1].  Rempel V, Fuchs A, Hinz S, et al. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS Med Chem Lett. 2012 Nov 14;4(1):41-5.

Chemical Properties

Cas No. 20601-85-8 SDF
别名 二丙基联苯二醇,Magnolignan
化学名 5,5'-dipropyl-[1,1'-biphenyl]-2,2'-diol
Canonical SMILES OC(C=CC(CCC)=C1)=C1C2=CC(CCC)=CC=C2O
分子式 C18H22O2 分子量 270.4
溶解度 ≤20mg/ml in ethanol;16mg/ml in DMSO;20mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.6982 mL 18.4911 mL 36.9822 mL
5 mM 0.7396 mL 3.6982 mL 7.3964 mL
10 mM 0.3698 mL 1.8491 mL 3.6982 mL
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