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Tetradecanedioic acid Sale

(Synonyms: 十四烷二酸) 目录号 : GC61325

Tetradecanedioic acid (Tetradecanedicarboxylate) is a C14 dicarboxylic acid.

Tetradecanedioic acid Chemical Structure

Cas No.:821-38-5

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500mg
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产品描述

Tetradecanedioic acid (Tetradecanedicarboxylate) is a C14 dicarboxylic acid.

Chemical Properties

Cas No. 821-38-5 SDF
别名 十四烷二酸
Canonical SMILES OC(=O)CCCCCCCCCCCCC(O)=O
分子式 C14H26O4 分子量 258.36
溶解度 储存条件 Store at -20°C
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溶解性数据

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1 mM 3.8706 mL 19.3528 mL 38.7057 mL
5 mM 0.7741 mL 3.8706 mL 7.7411 mL
10 mM 0.3871 mL 1.9353 mL 3.8706 mL
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Research Update

Metabolic engineering for the production of dicarboxylic acids and diamines

Metab Eng 2020 Mar;58:2-16.PMID:30905694DOI:10.1016/j.ymben.2019.03.005.

Microbial production of chemicals and materials from renewable carbon sources is becoming increasingly important to help establish sustainable chemical industry. In this paper, we review current status of metabolic engineering for the bio-based production of linear and saturated dicarboxylic acids and diamines, important platform chemicals used in various industrial applications, especially as monomers for polymer synthesis. Strategies for the bio-based production of various dicarboxylic acids having different carbon numbers including malonic acid (C3), succinic acid (C4), glutaric acid (C5), adipic acid (C6), pimelic acid (C7), suberic acid (C8), azelaic acid (C9), sebacic acid (C10), undecanedioic acid (C11), dodecanedioic acid (C12), brassylic acid (C13), Tetradecanedioic acid (C14), and pentadecanedioic acid (C15) are reviewed. Also, strategies for the bio-based production of diamines of different carbon numbers including 1,3-diaminopropane (C3), putrescine (1,4-diaminobutane; C4), cadaverine (1,5-diaminopentane; C5), 1,6-diaminohexane (C6), 1,8-diaminoctane (C8), 1,10-diaminodecane (C10), 1,12-diaminododecane (C12), and 1,14-diaminotetradecane (C14) are revisited. Finally, future challenges are discussed towards more efficient production and commercialization of bio-based dicarboxylic acids and diamines.

Enhancement of α,ω-Dicarboxylic Acid Production by the Expression of Xylose Reductase for Refactoring Redox Cofactor Regeneration

J Agric Food Chem 2018 Apr 4;66(13):3489-3497.PMID:29537267DOI:10.1021/acs.jafc.8b00376.

The production of α,ω-dicarboxylic acids (DCAs) by whole-cell biocatalysis is often limited by cofactor regeneration. Here, ω-oxidation pathway genes (monooxygenase, alcohol dehydrogenase, and aldehyde dehydrogenase) were coexpressed with a xylose reductase (XR) gene to regenerate cofactors in an engineered Escherichia coli strain that cometabolizes glucose and xylose. The resulting strain exhibited a 180% increase in DCA production compared with the control strain without XR, and produced xylitol in the presence of xylose. Expression of monooxygenase and XR without other ω-oxidation pathway genes resulted in an additional increase in Tetradecanedioic acid concentration and a substrate conversion of 95%, which was 198% higher than that associated with the control strain. The expression of XR helped the system to regenerate and balance the cofactors thereby achieving maximum substrate conversion efficiency. It could serve as an efficient platform for the industrial production of α,ω-DCAs.

[Degradation of fatty acid by syntrophic hydrocarbon-degrading consortium M82]

Wei Sheng Wu Xue Bao 2014 Nov 4;54(11):1369-77.PMID:25752144doi

Objective: Using molecular ecology methods, we screened non-hydrocarbon carbon sources suitable for growth of syntrophic hydrocarbon-degrading Syntrophus sp. Methods: The acclimated methanogenic hexadecane-degrading consortium M82 was subcultured with dodecanedioic acid, Tetradecanedioic acid, hexadecanoic acid, propionate and lactate. PCR-DGGE and qPCR were used to analyze the abundance and quantity of syntrophaceae using different carbon sources. The T-RFLP was applied to analyze archaeal community. Results: The consortium M82 could grow and produce methane using a variety of fatty acids that also resulted in the change in bacterial microbial community structure. Syntrophaceae bacterial stripe was obviously detected in the culture added additional dodecanedioic acid and Tetradecanedioic acid. Furthermore, the results show that the logarithmic abundance of Syntrophaceae was 7.4 and 7.6 in per milliliter culture in the two enrichment cultures respectively, which were 2 - 3 units higher than these in other cultures. The archaeal community structure was mainly composed of acetoclastic methanogens Methanosaeta and hydrogenotrophic methanogens Methanoculleus in all culture. Conclusion: Syntrophus sp. can use non-hydrocarbon carbon source (dodecanedioic acid and Tetradecanedioic acid) as substrate to grow, which provides valuable information to isolate syntrophic hydrocarbon bacteria, and reveal the molecular mechanism of syntrophic hydrocarbon degradation.

Identification of unknown impurity of azelaic acid in liposomal formulation assessed by HPLC-ELSD, GC-FID, and GC-MS

AAPS PharmSciTech 2014 Feb;15(1):111-20.PMID:24166667DOI:10.1208/s12249-013-0038-y.

The identification of new contaminants is critical in the development of new medicinal products. Many impurities, such as pentanedioic acid, hexanedioic acid, heptanedioic acid, octanedioic acid, decanedioic acid, undecanedioic acid, dodecanedioic acid, tridecanedioic acid, and Tetradecanedioic acid, have been identified in samples of azelaic acid. The aim of this study was to identify impurities observed during the stability tests of a new liposomal dosage form of azelaic acid that is composed of phosphatidylcholine and a mixture of ethyl alcohol and water, using high-performance liquid chromatography with evaporative light-scattering detector (HPLC-ELSD), gas chromatography-flame ionisation detection (GC-FID), and gas chromatography-mass spectrometry (GC-MS) methods. During the research and development of a new liposomal formulation of azelaic acid, we developed a method for determining the contamination of azelaic acid using HPLC-ELSD. During our analytical tests, we identified a previously unknown impurity of a liposomal preparation of azelaic acid that appeared in the liposomal formulation of azelaic acid during preliminary stability studies. The procedure led to the conclusion that the impurity was caused by the reaction of azelaic acid with one of the excipients that was applied in the product. The impurity was finally identified as an ethyl monoester of azelaic acid. The identification procedure of this compound was carried out in a series of experiments comparing the chromatograms that were obtained via the following chromatographic methods: HPLC-ELSD, GC-FID, and GC-MS. The final identification of the compound was carried out by GC with MS.

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys

Drug Metab Dispos 2018 Feb;46(2):178-188.PMID:29162614DOI:10.1124/dmd.117.077586.

Perturbation of organic anion transporter (OAT) 1- and OAT3-mediated transport can alter the exposure, efficacy, and safety of drugs. Although there have been reports of the endogenous biomarkers for OAT1/3, none of these have all of the characteristics required for a clinical useful biomarker. Cynomolgus monkeys were treated with intravenous probenecid (PROB) at a dose of 40 mg/kg in this study. As expected, PROB increased the area under the plasma concentration-time curve (AUC) of coadministered furosemide, a known substrate of OAT1 and OAT3, by 4.1-fold, consistent with the values reported in humans (3.1- to 3.7-fold). Of the 233 plasma metabolites analyzed using a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics method, 29 metabolites, including pyridoxic acid (PDA) and homovanillic acid (HVA), were significantly increased after either 1 or 3 hours in plasma from the monkeys pretreated with PROB compared with the treated animals. The plasma of animals was then subjected to targeted LC-MS/MS analysis, which confirmed that the PDA and HVA AUCs increased by approximately 2- to 3-fold by PROB pretreatments. PROB also increased the plasma concentrations of hexadecanedioic acid (HDA) and Tetradecanedioic acid (TDA), although the increases were not statistically significant. Moreover, transporter profiling assessed using stable cell lines constitutively expressing transporters demonstrated that PDA and HVA are substrates for human OAT1, OAT3, OAT2 (HVA), and OAT4 (PDA), but not OCT2, MATE1, MATE2K, OATP1B1, OATP1B3, and sodium taurocholate cotransporting polypeptide. Collectively, these findings suggest that PDA and HVA might serve as blood-based endogenous probes of cynomolgus monkey OAT1 and OAT3, and investigation of PDA and HVA as circulating endogenous biomarkers of human OAT1 and OAT3 function is warranted.