surface antigen (208-215) [Hepatitis B Virus]
(Synonyms: H2N-Ile-Leu-Ser-Pro-Phe-Leu-Pro-Leu-OH ) 目录号 : GP10068
Surface antigen used for signs of infection
![surface antigen (208-215) [Hepatitis B Virus] Chemical Structure](/media/struct/GP1/GP10068.png "surface antigen (208-215) [Hepatitis B Virus] Chemical Structure")
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
The nucleocapsid of hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated, and they have been proposed to represent the phenotypic expression of the four major genotypes of HBV1. HBsAg subtypes show distinct geographical distributions2 and may provide historical information on the migration of ancestors carrying HBV of a particular subtype3.
The HBsAg, localized on the surface of the infectious Dane particle is considered to be the antigen responsible for conferring immunity to infection with hepatitis B4. A larger amount is found on filaments of 20-nm diameter and variable length. By far the most HBsAg is present on small, noninfectious, 20-nm particles5.
Refences:
1.Le Bouvier, G. L., Mccollum, R. W., Hierholzer, W. J., Irwin, G. R., Krugman, S. & Giles, J. P. (1972). Subtypes of Australia antigen and hepatitis-B virus. Journal of the American Medical Association 222, 928-930
2.Courouce-Pauty, A. M., Plancon, A. & Soulier, J. P. (1983). Distribution of HBsAg subtypes in the world. Vox sanguinis 44, 197-211.
3.Yamashita, Y., Kurashina, S., Miyakawa, Y. & Mayumi, M. (1975). South-to-north gradient in distribution of the r determinant of hepatitis B surface antigen in Japan. Journal of Infectious Diseases 131, 567-569.
4.A. M. Moriarty, B. H. Hoyer et al. Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector. Proc. Nati. Acad. Sci. 78: 2606-2610(1981).
| Cas No. | SDF | ||
| 别名 | H2N-Ile-Leu-Ser-Pro-Phe-Leu-Pro-Leu-OH | ||
| Canonical SMILES | NC(C(C)CC)C(NC(C(NC(CO)C(N1CCCC1C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C(N3CCCC3C(NC(C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)CC(C)C)=O | ||
| 分子式 | C46H74N8O10 | 分子量 | 899.13 |
| 溶解度 | ≥ 89.9mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1122 mL | 5.5609 mL | 11.1219 mL |
| 5 mM | 0.2224 mL | 1.1122 mL | 2.2244 mL |
| 10 mM | 0.1112 mL | 0.5561 mL | 1.1122 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。