Home>>Signaling Pathways>> Antibody-drug Conjugate/ADC Related>> ADC Linker>>SPDP (SPDP Crosslinker)
SPDP (SPDP Crosslinker) 目录号 GC30018

SPDP是硫化氨的短链交联剂,能够通过NHS脂激活形成二硫键。

规格 价格 库存 购买数量
10mg
¥491.00
现货
50mg
¥1,339.00
现货
100mg
¥2,231.00
现货
200mg
¥3,213.00
现货
500mg
¥6,694.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

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Chemical Properties

Cas No. 68181-17-9 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
分子式 C12H12N2O4S2 分子量 312.36
溶解度 DMSO : 155 mg/mL (496.22 mM) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .

[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.