| SPDP (SPDP Crosslinker) 目录号 GC30018 |
Sample solution is provided at 25 µL, 10mM.
SPDP (SPDP Crosslinker) Dilution Calculator
SPDP (SPDP Crosslinker) Molarity Calculator
| Cas No. | 68181-17-9 | SDF | Download SDF |
| 别名 | N/A | ||
| 化学名 | N/A | ||
| Canonical SMILES | O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2 | ||
| 分子式 | C12H12N2O4S2 | 分子量 | 312.36 |
| 溶解度 | DMSO : 155 mg/mL (496.22 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .
[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.