Home>>Signaling Pathways>> GPCR/G protein>> CXCR>>SB 265610

SB 265610

目录号 : GC13458

A selective CXCR2 inverse agonist

SB 265610 Chemical Structure

Cas No.:211096-49-0

规格 价格 库存 购买数量
1mg
¥1,039.00
现货
5mg
¥1,391.00
现货
10mg
¥2,225.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

SB 265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated Ca2+ mobilization with  IC50 value of 3.4nM [1] [2].
CXCR2 is an integral membrane protein that specifically binds and responds to cytokines of the CXC chemokine family.
In isolated rat neutrophils stimulated with rat CINC-1, SB 265610 inhibited Ca2+ mobilization induced by CINC-1 with IC50 value of 3.4 nM in a dose-dependent way, while inhibited Ca2+ mobilization induced by C5a only with IC50 value of  6.8uM, which showed selectivity of the antagonist for CXCR2 [1]. In equilibrium saturation binding studies, SB265610 inhibited the binding of interleukin-8 without affecting the Kd. While, IL-8 couldn’t prevent binding of SB265610. SB265610 is an allosteric inverse agonist at the CXCR2 receptor [2].
In a hyperoxia rat model, newborn rats increased lung neutrophil content. Treatment with SB-265610 reduced hyperoxia-induced neutrophil accumulation in bronchoalveolar lavage and whole lung myeloperoxidase accumulation [1].
References:
[1]. Auten RL, Richardson RM, White JR, et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther, 2001, 299(1): 90-95.
[2]. Bradley ME, Bond ME, Manini J, et al. SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor. Br J Pharmacol, 2009, 158(1): 328-338.

Chemical Properties

Cas No. 211096-49-0 SDF
化学名 1-(2-bromophenyl)-3-(7-cyano-2H-benzo[d][1,2,3]triazol-4-yl)urea
Canonical SMILES BrC1=CC=CC=C1NC(NC2=CC=C(C#N)C3=NNN=C23)=O
分子式 C14H9BrN6O 分子量 357.16
溶解度 3mg/mL in DMSO, 3mg/mL in DMF, 5mg/mL in Ethanol 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.7999 mL 13.9993 mL 27.9987 mL
5 mM 0.56 mL 2.7999 mL 5.5997 mL
10 mM 0.28 mL 1.3999 mL 2.7999 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置