Home>>Signaling Pathways>> Microbiology & Virology>> Arenavirus>>Retro-2

Retro-2 Sale

(Synonyms: RN 1-001) 目录号 : GC18485

A selective inhibitor of retrograde protein trafficking mediated by syntaxin-5

Retro-2 Chemical Structure

Cas No.:1429192-00-6

规格 价格 库存 购买数量
10mM 1 mL in DMSO
¥842.00
现货
5mg
¥765.00
现货
10mg
¥1,260.00
现货
50mg
¥3,780.00
现货
100mg
¥6,120.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways. Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 uM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 uM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 uM, respectively). In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.

Chemical Properties

Cas No. 1429192-00-6 SDF
别名 RN 1-001
化学名 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
Canonical SMILES O=C1C2=CC=CC=C2NC(C3=CC=C(C)S3)N1C4=CC=CC=C4
分子式 C19H16N2OS 分子量 320.4
溶解度 DMSO : ≥ 125 mg/mL (390.13 mM);Water : < 0.1 mg/mL (insoluble) 储存条件 Store at -20°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 3.1211 mL 15.6055 mL 31.211 mL
5 mM 0.6242 mL 3.1211 mL 6.2422 mL
10 mM 0.3121 mL 1.5605 mL 3.1211 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置