Reverse Transcriptase(逆转录酶)
Reverse transcriptase, also known as RNA-directed DNA polymerase catalyzes the transcription of RNA into DNA. It is key to the retroviruses infection.
Products for Reverse Transcriptase
- Cat.No. 产品名称 Information
- GC70089 Ulonivirine Ulonivirine (MK-8507) 是一种具有口服活性的非核苷逆转录酶(reverse transcriptase)抑制剂,具有较高的抗病毒活性。Ulonivirine 可用于 HIV-1 感染的研究。
- GC25867 Rilpivirine Hydrochloride Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.
- GC65207 R-10015 R-10015 is a potent, selective inhibitor of LIM domain kinase (LIMK) with IC50 of 38 nM for human LIMK1. R-10015 binds to the ATP-binding pocket and acts as a broad-spectrum antiviral compound for HIV infection.
- GC65085 3'-Azido-3'-deoxy-5-methylcytidine 3'-Azido-3'-deoxy-5-methylcytidine (CS-92) 是一种有效的异嗜性小鼠白血病相关逆转录病毒 (XMRV) 抑制剂,作用于 MCF-7 细胞,CC50 为 43.5 μM。3'-Azido-3'-deoxy-5-methylcytidine (CS-92) 作用于外周血单核细胞 (PBM),抑制 HIV-1 逆转录酶,EC50 为 0.06 μM。
- GC64590 Dexelvucitabine Dexelbucitabine (Reverset; d-d4FC) 是一种胞苷 类似物,一种具有口服活性的核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂。Dexelbucitabine 是一种有效的抗 HIV-1 病毒剂,这些病毒聚合酶中含有胸苷类似物和/或 M184V 突变。Dexelvucitabine 是一种 2'-脱氧胞苷抗逆转录病毒剂。
- GC64261 Censavudine Censavudine (OBP-601; BMS-986001),一种核苷类似物,是一种核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂。Censavudine 是一种有效的 HIV 抑制剂,对 HIV-2 和 HIV-1 的 EC50 范围分别为 30-81 nM 和 450-890 nM。
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GC63541
FNC-TP
FNC-TP 是 FNC 的细胞内活性形式。FNC 是一种有效的核苷逆转录酶抑制剂 (NRTI),对 HIV、HBV 和 HCV 具有抗病毒活性。
- GC63486 Stampidine Stampidine 是一种核苷逆转录酶抑制剂 (NRTI),具有高效、广谱的抗 HIV 活性。Stampidine 抑制实验室 HIV-1 株 HTLVIIIB (B 包膜亚型) 和主要临床分离株的 IC50 值分别为 1 nM 和 2 nM。Stampidine 还可以抑制耐 NRTI 临床分离株和耐 NNRTI 临床分离株,IC50 分别为 8.7 nM 和 11.2 nM 。
- GC49022 Didanosine-d2 An internal standard for the quantification of didanosine
- GC62607 EFdA-TP tetraammonium EFdA-TP tetraammonium 是一种有效的核苷逆转录酶 (RT) 抑制剂。EFdA-TP tetraammonium 作为有效的立即或延迟链终止剂 (ICT 或 DCT) 抑制 RT 催化的 DNA 合成。EFdA-TP tetraammonium 通过多种机制抑制 HIV-1 RT。
- GC62223 Ro-0335 An NNRTI and active metabolite of elsulfavirine
- GC47770 Nevirapine-d4 An internal standard for the quantification of nevirapine
- GC46767 Abacavir-d4 An internal standard for the quantification of abacavir
- GC61134 Nigranoic acid Nigranoicacid是五味子中分离得到的一种三萜类化合物。Nigranoicacid能抑制HIV-1逆转录酶。在脑缺血再灌注动物模型中,Nigranoicacid通过PARP/AIF信号通路保护大脑。
- GC60358 Tenofovir diphosphate triethylamine Tenofovirdiphosphatetriethylamine(TFV-DPtriethylamine)是一种ATP竞争性的DNA聚合酶(DNApolymerases)抑制剂,且是1型HIV(HIV-1)逆转录酶(RT)的底物。
- GC60357 Tenofovir diphosphate An HIV reverse transcriptase and HBV polymerase inhibitor
- GC45825 Etravirine-d6 An internal standard for the quantification of etravirine
- GC37760 Tenofovir Disoproxil A prodrug of the antiviral tenofovir
- GC37759 Tenofovir alafenamide hemifumarate Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
- GC37758 Tenofovir alafenamide fumarate Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
- GC37690 Stavudine sodium An inhibitor of HIV reverse transcriptase
- GC37674 SPK-601 SPK-601(LMV-601)是卵磷脂特异磷脂酶C(PC-PLC)抑制剂,可用作抗菌剂。
- GC35835 Delavirdine A non-nucleoside reverse transcriptase inhibitor
- GC35731 Corydine An aporphine alkaloid with diverse biological activities
- GC35130 4'-Ethynyl-2'-deoxyadenosine 4'-Ethynyl-2'-deoxyadenosine (4'-E-dA),是一种核苷逆转录酶 (RT) 抑制剂, 是一种抗病毒药物,对耐药HIV变异型具有较强的抑制作用,在MT-4细胞中,EC50 值为 98 nM。
- GC43600 Emtricitabine S-oxide A potential impurity found in commercial emtricitabine preparations
- GC42731 Adefovir An active metabolite of adefovir dipivoxil
- GC33990 2,2'-Anhydrouridine (2,2'-Cyclouridine) An inhibitor of uridine phosphorylase
- GC33536 Etravirine D4 (TMC-125 D4) Etravirine D4 (TMC-125 D4) (TMC-125 D4) 是氘标记的 Etravirine。
- GC32381 BF738735 BF738735是一种磷脂酰肌醇4-激酶IIIβ(PI4KIIIβ)抑制剂,IC50为5.7nM。
- GC32358 Loviride (R 89439) Loviride (R 89439) (R 89439) 是一种非核苷类逆转录酶抑制剂 (NNRTI),抑制 HIV-1 逆转录酶的 IC50 为 0.3 μM。
- GC32306 Islatravir (MK-8591) A nucleoside reverse transcriptase inhibitor
- GC19126 Doravirine A non-nucleoside reverse transcriptase inhibitor
- GC10084 Pyridoxal 5 phosphate An enzyme cofactor
- GC10387 3'-Azido-3'-deoxythymidine β-D-glucuronide (sodium salt) A zidovudine metabolite
- GC12679 GS-7340 A prodrug from of tenofovir
- GC11744 AG 555 A tyrphostin EGFR inhibitor
- GC16841 Adefovir Dipivoxil An antiviral prodrug
- GC12830 Stavudine (d4T) An inhibitor of HIV reverse transcriptase
- GC15996 Etravirine (TMC125) An NNRTI
- GC11274 Abacavir sulfate An antiviral nucleoside analog
- GC14720 Zalcitabine A nucleoside reverse transcriptase inhibitor
- GC15488 Tenofovir maleate An HIV and HBV antiviral
- GC13846 Tenofovir hydrate An HIV and HBV antiviral
- GC12389 Efavirenz A non-nucleoside reverse transcriptase inhibitor
- GC15452 Delavirdine mesylate A non-nucleoside reverse transcriptase inhibitor
- GC14452 Dapivirine (TMC120) A non-nucleoside reverse transcriptase inhibitor
- GC13653 Emtricitabine A nucleoside reverse transcriptase inhibitor
- GC15330 Didanosine An antiviral nucleoside analog and inhibitor of reverse transcriptase
- GC16387 Nevirapine An NNRTI