Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> ULK

ULK(UNC-51样激酶)

ULK1, a serine/threonine protein kinase, is an enzyme that in humans is encoded by the ULK1 gene. ULK1 is essential for the initial stages of autophagy. ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.

ULK2 is essential for astrocyte transformation and tumor growth. ULK2 also inhibits the growth of glioma cells, which requires autophagy induction as kinase mutant of ULK2 fails to induce autophagy and inhibit growth. ULK2 and its homologue ULK1 are only down-regulated in all grades of glioma. Thus these results altogether suggest that inhibition of autophagy by ULK1/2 down-regulation is essential for glioma development.

Products for  ULK

  1. Cat.No. 产品名称 Information
  2. GC62146 XST-14 XST-14 是一种有效的,竞争性强且高度选择性的 ULK1 抑制剂,IC50 为 26.6 nM。XST-14 通过减少 ULK1 下游底物的磷酸化来诱导自噬抑制。XST-14 诱导肝细胞癌 (HCC) 细胞凋亡,并具有抗肿瘤作用。
  3. GC60891 GW406108X GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
  4. GC36654 MRT68921 dihydrochloride An inhibitor of ULK1/2
  5. GC36517 LYN-1604 hydrochloride A ULK1 activator
  6. GC34315 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
  7. GC19236 LYN-1604 A ULK1 activator
  8. GC14086 MRT68921 An inhibitor of ULK1/2
  9. GC15654 SBI-0206965 An ULK1 and ULK2 inhibitor
  10. GC17136 MRT67307 A kinase inhibitor

9 Item(s)

per page

Set Descending Direction