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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Mitophagy

Mitophagy(线粒体自噬)

Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Products for  Mitophagy

  1. Cat.No. 产品名称 Information
  2. GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) 是 Valproic acid 的氘代物。Valproic acid (VPA; 2-Propylpentanoic Acid) 是一种 HDAC 抑制剂，IC50 值为 0.5-2 mM，抑制 HDAC1 的活性，(IC50，400 μM)，同时可诱导 HDAC2 的降解。Valproic acid 激活 Notch1 信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid 可用于癫痫、双相情感障碍和偏头痛等的研究。
  3. GC64098 Isoniazid-d4 Isoniazid-d4 (INH-d4) 是 Isoniazid 的氘代物。Isoniazid (INH) 是一种前药，必须被细菌过氧化氢酶 KatG 激活。Isoniazid 对快速分裂的分枝杆菌具有杀菌作用，并具有抗菌活性。
  4. GC64032 Salicylic acid-d6 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) 是 Salicylic acid 的一种氘代化合物。Salicylic acid 抑制 COX-2 活性，抑制作用与转录因子 (NF-κB) 激活无关。
  5. GC62637 AUTAC4 AUTAC4 是一种靶向线粒体的自噬靶向嵌合体 (AUTAC)。AUTAC4 下调细胞质蛋白并通过线粒体自噬促进靶向线粒体更新。
  6. GC62135 BC1618 An inhibitor of FBXO48
  7. GC61809 Olanzapine D3 OlanzapineD3(LY170053D3)是Olanzapine的氘代物。Olanzapine是一种选择性单胺能拮抗剂，高亲和力结合5-羟色胺H1，5HT2A/2C，5HT3，5HT6(Ki分别为7、4、11、57和5nM)，多巴胺D1-4(Ki=11-31nM)，毒蕈碱M1-5(Ki=1.9-25nM)和肾上腺素α1受体(Ki=19nM)。Olanzapine是一种非典型的抗精神病剂。
  8. GC48118 Sunitinib-d10 An internal standard for the quantification of sunitinib
  9. GC61229 Quinacrine dihydrochloride Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
  10. GC61227 Quercetin D5 QuercetinD5是Quercetin的一种氘代化合物。Quercetin是一种天然黄酮类化合物，可激活或抑制许多蛋白质的活性。Quercetin可激活SIRT1，也可抑制PI3K，抑制PI3Kγ，PI3Kδ，PI3Kβ的IC50分别为2.4μM,3.0μM,5.4μM。
  11. GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin
  12. GC60245 Metformin

    二甲双胍（Metformin 1,1-二甲基双胍）主要介导AMPK的激活，AMPK是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶，导致癌细胞mTOR信号和蛋白质合成的减少。
  13. GC60241 Melatonin D5 An internal standard for the quantification of melatonin
  14. GC38562 P62-mediated mitophagy inducer P62-mediated mitophagy inducer 是一种线粒体自噬调节剂，能激活线粒体噬但不招募 Parkin 或者使膜电位崩溃，且在缺乏完整功能的 PINK1/Parkin 通路的细胞中保留活性。
  15. GC38150 Liensinine Diperchlorate Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.
  16. GC36930 Pitavastatin D4 Pitavastatin D4是Pitavastatin氘代化合物标准品。
  17. GC45099 U-0126

    A MEK inhibitor and AMPK activator
  18. GC40775 Dexamethasone A synthetic glucocorticoid
  19. GC34817 Sulfosuccinimidyl oleate sodium

    An irreversible inhibitor of CD36
  20. GC40226 Curcumin-d6 An internal standard for the quantification of curcumin
  21. GC32768 Quinacrine dihydrochloride (Mepacrine dihydrochloride) Quinacrine是一种荧光探针，使胆碱能受体蛋白发生构象转变，低μM水平对AML细胞具有作用活性，平均IC50为2.30μM。
  22. GC32078 Clioquinol (Iodochlorhydroxyquin)

    A metal-chelating antimicrobial agent
  23. GC31964 Sulfosuccinimidyl oleate

    An irreversible inhibitor of CD36
  24. GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) Oxidopamine (6-OHDA) hydrochloride 是神经递质多巴胺的拮抗剂。
  25. GC30360 Cresol (Cresol mixture of isomers) Cresol是一种有机化合物，是芳香族有机化合物广泛存在的天然及合成基团。
  26. GC14591 Hemin chloride An oxidized form of heme
  27. GC13554 Deferoxamine mesylate An iron chelator and inhibitor of prolyl hydroxylases
  28. GC18049 GSK2578215A A potent LRRK2 inhibitor
  29. GC16267 6-Hydroxydopamine hydrobromide A catecholaminergic neurotoxin
  30. GC16105 Iohexol A contrast reagent
  31. GC12017 Isoniazid An inhibitor of mycolic acid synthesis
  32. GC14968 Esmolol HCl A β1-AR antagonist
  33. GC17683 Brefeldin A

    布雷菲定A（BFA）是一种真菌大环内酯，能够有效、可逆地抑制细胞内囊泡形成和内质网（ER）与高尔基体之间的蛋白质运输。
  34. GC17340 Carbamazepine 卡马西平是一种钠通道阻滞剂，是一种抗惊厥药。
  35. GC16508 Salicylic acid An Analytical Reference Standard
  36. GC11332 Pitavastatin Pitavastatin (NK-104) 是一种有效的羟甲基戊二酰辅酶A (HMG-CoA) 还原酶抑制剂。
  37. GC17443 Metformin HCl

    A biguanide with diverse biological activities
  38. GC11237 Dexamethasone acetate An acetate form of dexamethasone
  39. GC12495 Olanzapine An atypical antipsychotic
  40. GC10580 AICAR phosphate

    An activator of AMPK
  41. GC11424 Valproic acid A class I HDAC inhibitor
  42. GC13001 SB 203580 hydrochloride A water soluble p38 MAPK inhibitor
  43. GC17651 Sunitinib Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶抑制剂，对 VEGFR2 和 PDGFRβ 的 IC50 分别为 80 nM 和 2 nM。 Sunitinib 是一种 ATP 竞争性抑制剂，通过抑制自身磷酸化和随后的 RNase 激活，有效抑制 Ire1α 的自身磷酸化。
  44. GC10585 Simvastatin (Zocor) An HMG-CoA reductase inhibitor
  45. GC12116 Pitavastatin Calcium An HMG-CoA reductase inhibitor
  46. GC10710 3-Methyladenine

    3-甲基腺嘌呤是一种经典的自噬抑制剂。
  47. GC15904 PP242 Potent inhibitor of mTOR kinase in both mTORC1 and mTORC2
  48. GC15617 Etoposide

    An inhibitor of topoisomerase II
  49. GC13443 Doxazosin Mesylate An α1-AR antagonist
  50. GC12339 Ivermectin A mixture of ivermectin B1a and ivermectin B1b
  51. GC15618 Melatonin

    An indoleamine neurohormone that entrains circadian rhythms

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