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Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Products for  Mitophagy

  1. Cat.No. Product Name Information
  2. GC11720 17-AAG (KOS953) Hsp90 inhibitor
  3. GC10710 3-Methyladenine Class III PI3K inhibitor
  4. GC16267 6-Hydroxydopamine hydrobromide An antagonist of the neurotransmitter dopamine
  5. GC17234 ABT-737

    Bcl-2 inhibitor

  6. GC10518 AICAR AMPK activator
  7. GC10580 AICAR phosphate AMPK activator
  8. GC15706 Aspirin (Acetylsalicylic acid)

    Cyclooxygenase (COX) inhibitor

  9. GC62637 AUTAC4 AUTAC4 是一种靶向线粒体的自噬靶向嵌合体 (AUTAC)。AUTAC4 下调细胞质蛋白并通过线粒体自噬促进靶向线粒体更新。
  10. GC62135 BC1618 BC1618,是具有口服活性的 Fbxo48 抑制剂,可刺激 Ampk 信号 (阻止激活的 pAmpkα 被 Fbxo48 介导的蛋白酶体降解)。BC1618 促进线粒体分裂、促进自噬,提高肝脏胰岛素的敏感性。
  11. GC10480 Betulinic acid Anti-HIV and antitumor compound,pentacyclic triterpenoid
  12. GC17683 Brefeldin A ATPase inhibitor
  13. GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels
  14. GC15083 Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent
  15. GC32078 Clioquinol (Iodochlorhydroxyquin) Clioquinol(Iodochlorhydroxyquin)是一抗真菌化合物,近来被研究发现有抗AD和抗肿瘤活性。
  16. GC14787 Curcumin A tyrosinase inhibitor
  17. GC40226 Curcumin-d6 Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.
  18. GC13554 Deferoxamine mesylate An iron-chelating agent
  19. GC40775 Dexamethasone A glucocorticoid receptor agonist
  20. GC11237 Dexamethasone acetate

    IL Receptor modulator

  21. GC13443 Doxazosin Mesylate α1-adrenergic receptor antagonist

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