E3 Ligase(E3 连接酶)
E3 ligases perform the last step in the ubiquitination cascade. They transfer the ubiquitin from the active site cysteine of E2 enzyme to the substrate lysine or N terminus. The loss of function or mis-targeting of the E3 ligases are associated with various cancer types.
Products for E3 Ligase
- Cat.No. 产品名称 Information
- GC25019 5-amino-2,4-dimethylpyridine (5A-DMP) 5-amino-2,4-dimethylpyridine (5A-DMP) is a novel tandem Tudor domain (TTD)-binding compound that inhibits the full-length UHRF1:LIG1 interaction in Xenopus egg extracts
- GC50234 N106 An activator of SERCA2A sumoylation
- GC44291 NAB 2 An inhibitor of α-synuclein-induced toxicity
- GC10940 PRT 4165 An inhibitor of PRC1 ubiquitin ligases
- GC15492 SMER 3 A selective inhibitor of SCFMET30 ubiquitin E3 ligase
- GC11869 SZL P1-41 An inhibitor of Skp2
- GC15017 NSC 624206 An inhibitor of ubiquitin-activating enzyme (E1)