Autophagy
Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.
- Cat.No. Product Name Information
-
GC30761
α-Hydroxylinoleic acid
α-Hydroxylinoleicacid是一种脂肪酸,是Salvianilotica种子中油的组分之一。
-
GC46008
(±)-Thalidomide-d4
-
GC34960
(+)-Talarozole
(+)-Talarozole 是视黄酸代谢的有效抑制剂,来自专利 WO 1997049704 A1。
-
GC10603
(-)-epicatechin gallate
major catechin in green tea
-
GC17242
(-)-epigallocatechin
green tea epicatechin
-
GC14049
(-)-Epigallocatechin gallate (EGCG)
Antioxidant, antiangiogenic and antitumor agent
-
GC31386
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer)
(-)-PX20606transisomer是一种FXR激动剂,在FRET和M1H测定中对于FXR的EC50值分别为18和29nM。
-
GC60395
(3S,5R)-Fluvastatin D6
(3S,5R)-FluvastatinD6是(3S,5R)-Fluvastatinsodium的氘代物。Fluvastatin是第一个完全合成的,竞争性的HMG-CoAreductase还原酶抑制剂,IC50为8nM。Fluvastatin通过依赖Nrf2的抗氧化通路保护血管平滑肌细胞免受氧化应激。
-
GC49189
(E/Z)-4-hydroxy Tamoxifen-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
-
GC34096
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))
(R)-(-)-Gossypolaceticacid(AT-101(aceticacid))是天然产物Gossypol的左旋异构体。AT-101结合到Bcl-2,Mcl-1和Bcl-xL蛋白,Ki值分别为260±30nM,170±10nM和480±40nM。
-
GC31665
(R)-BPO-27
(R)-BPO-27是有效的CFTR抑制剂,IC50值为4nM。
-
GC62528
(Rac)-Hesperetin
(Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质,为有效的,广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。
-
GC13136
(S)-Crizotinib
Potent MTH1 inhibitor
-
GC14820
(S)-Naproxen
non-selective COX inhibitor
-
GC15015
(±)-Bay K 8644
L-type Ca2+-channel activator
-
GC35068
1-Monomyristin
1-Monomyristin 提取自 Serenoa repens,抑制 2-油酰甘油的水解 (IC50=32 μM) 和脂肪酸酰胺水解酶 (FAAH) 活性 (IC50=18 μM)。1-Monomyristin 对金黄色葡萄球菌和聚集性放线菌有抗菌活性,对白色念珠菌也有抗真菌活性。
-
GC17295
10058-F4
C-Myc-Max dimerization inhibitor
-
GC14918
10074-G5
c-Myc inhibitor
-
GC11720
17-AAG (KOS953)
Hsp90 inhibitor
-
GC40947
2,3-Dimethoxy-5-methyl-p-benzoquinone
2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.
-
GC46057
2,5-Dihydroxycinnamic Acid phenethyl ester
-
GC15084
2-Methoxyestradiol (2-MeOE2)
Apoptotic, antiproliferative and antiangiogenic agent
-
GC30011
20-Deoxyingenol
20-去氧巨大戟萜醇是一天然化合物。
-
GC35112
3'-Hydroxypterostilbene
3'-Hydroxypterostilbene,一种天然紫檀芪类似物,通过诱导细胞凋亡 (apoptosis) 和自噬 (autophagy),有效抑制人结肠癌细胞的生长 (对 COLO 205,HCT-116 和 HT-29 细胞的 IC50 分别为 9.0,40.2 和 70.9 μM)。3'-Hydroxypterostilbene 抑制 PI3K/Akt/mTOR/p70S6K 和 p38MAPK 途径并激活 ERK1/2,JNK1/2 MAPK途径。
-
GC12791
3,3'-Diindolylmethane
Anticancer and antineoplastic agent
-
GC10710
3-Methyladenine
Class III PI3K inhibitor
-
GC32767
3BDO
3BDO是一种新型mTOR激活剂,也能抑制自噬。
-
GC39658
4,4'-Dimethoxychalcone
4,4'-Dimethoxychalcone 可从植物当归中分离得到,是一种天然自噬 (autophagy) 诱导剂,具有抗衰老活性。
-
GC42414
4-hydroxy Tolbutamide
4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker.
-
GC35132
4-Hydroxylonchocarpin
4-Hydroxylonchocarpin 是一种查尔酮化合物,来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK,JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性,包括抗菌,抗癌,抗逆转录酶,抗结核,抗疟,抗炎和抗氧化活性。
-
GC13104
4E1RCat
Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction
-
GC30785
4E2RCat
4E2RCat是eIF4E-eIF4G相互作用的抑制剂,IC50值为13.5μM。
-
GC10468
4EGI-1
Competitive eIF4E/eIF4G interaction inhibitor
-
GC10946
5-Azacytidine
A DNA methyltransferase inhibitor
-
GN10241
5-Methoxypsoralen
Extracted from Cnidium monnieri (L.) cuss;Suitability:Boiling ethanol,acetic acid,propylene glycol,chloroform and benzene;Store the product in sealed,cool and dry condition
-
GC16267
6-Hydroxydopamine hydrobromide
An antagonist of the neurotransmitter dopamine
-
GN10228
6-Shogaol
Extracted from effective components of ginger。;Store the product in sealed, cool and dry condition
-
GN10449
7-Ethyl-10-hydroxycamptothecin
TOPO I inhibitor
-
GC12739
A 484954
A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor
-
GC17710
A-317491
P2X3 and P2X2/3 receptor antagonist
-
GC35211
A-317491 sodium salt hydrate
A-317491 sodium salt hydrate 是非核苷酸类P2X3和P2X2/3受体拮抗剂,能抑制由其介导的钙流。
-
GC15014
A-867744
Allosteric Modulator
-
GC11200
A23187
Ca2+ ionophore
-
GC14069
ABT-199
Bcl-2 inhibitor,potent and selective
-
GC17234
ABT-737
Bcl-2 inhibitor
-
GC15875
ABT-751 (E7010)
Inhibitor of microtubule polymerization,antimitotic
-
GC12422
ABT-888 (Veliparib)
A potent PARP inhibitor
-
GC10871
AC 55649
RARβ2 agonist, potent and selective
-
GC35228
Aceglutamide
Aceglutamide是一种精神兴奋剂和促智剂,用于改善记忆和集中注意力。
-
GC11567
Acetazolamide
carbonic anhydrase (CA) inhibitor