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Autophagy

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

  1. Cat.No. Product Name Information
  2. GC30761 α-Hydroxylinoleic acid α-Hydroxylinoleicacid是一种脂肪酸,是Salvianilotica种子中油的组分之一。
  3. GC46008 (±)-Thalidomide-d4
  4. GC34960 (+)-Talarozole (+)-Talarozole 是视黄酸代谢的有效抑制剂,来自专利 WO 1997049704 A1。
  5. GC10603 (-)-epicatechin gallate major catechin in green tea
  6. GC17242 (-)-epigallocatechin green tea epicatechin
  7. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent
  8. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606transisomer是一种FXR激动剂,在FRET和M1H测定中对于FXR的EC50值分别为18和29nM。
  9. GC60395 (3S,5R)-Fluvastatin D6 (3S,5R)-FluvastatinD6是(3S,5R)-Fluvastatinsodium的氘代物。Fluvastatin是第一个完全合成的,竞争性的HMG-CoAreductase还原酶抑制剂,IC50为8nM。Fluvastatin通过依赖Nrf2的抗氧化通路保护血管平滑肌细胞免受氧化应激。
  10. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
  11. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypolaceticacid(AT-101(aceticacid))是天然产物Gossypol的左旋异构体。AT-101结合到Bcl-2,Mcl-1和Bcl-xL蛋白,Ki值分别为260±30nM,170±10nM和480±40nM。
  12. GC31665 (R)-BPO-27 (R)-BPO-27是有效的CFTR抑制剂,IC50值为4nM。
  13. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质,为有效的,广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。
  14. GC13136 (S)-Crizotinib Potent MTH1 inhibitor
  15. GC14820 (S)-Naproxen non-selective COX inhibitor
  16. GC15015 (±)-Bay K 8644 L-type Ca2+-channel activator
  17. GC35068 1-Monomyristin 1-Monomyristin 提取自 Serenoa repens,抑制 2-油酰甘油的水解 (IC50=32 μM) 和脂肪酸酰胺水解酶 (FAAH) 活性 (IC50=18 μM)。1-Monomyristin 对金黄色葡萄球菌和聚集性放线菌有抗菌活性,对白色念珠菌也有抗真菌活性。
  18. GC17295 10058-F4 C-Myc-Max dimerization inhibitor
  19. GC14918 10074-G5 c-Myc inhibitor
  20. GC11720 17-AAG (KOS953) Hsp90 inhibitor
  21. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.

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