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Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC30761 α-Hydroxylinoleic acid α-Hydroxylinoleicacid是一种脂肪酸,是Salvianilotica种子中油的组分之一。
  3. GC46008 (±)-Thalidomide-d4
  4. GC34960 (+)-Talarozole (+)-Talarozole 是视黄酸代谢的有效抑制剂,来自专利 WO 1997049704 A1。
  5. GC10603 (-)-epicatechin gallate major catechin in green tea
  6. GC17242 (-)-epigallocatechin green tea epicatechin
  7. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent
  8. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606transisomer是一种FXR激动剂,在FRET和M1H测定中对于FXR的EC50值分别为18和29nM。
  9. GC62193 (1S,2S)-Bortezomib (1S,2S)-Bortezomib 是 Bortezomib 的对映异构体。Bortezomib 是一种细胞渗透性、可逆性和选择性的蛋白酶体抑制剂,通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki 为 0.6 nM)。Bortezomib 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib 是一种抗癌药物,也是第一种用于人类的蛋白酶体抑制剂。
  10. GC60395 (3S,5R)-Fluvastatin D6 (3S,5R)-FluvastatinD6是(3S,5R)-Fluvastatinsodium的氘代物。Fluvastatin是第一个完全合成的,竞争性的HMG-CoAreductase还原酶抑制剂,IC50为8nM。Fluvastatin通过依赖Nrf2的抗氧化通路保护血管平滑肌细胞免受氧化应激。
  11. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
  12. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypolaceticacid(AT-101(aceticacid))是天然产物Gossypol的左旋异构体。AT-101结合到Bcl-2,Mcl-1和Bcl-xL蛋白,Ki值分别为260±30nM,170±10nM和480±40nM。
  13. GC31665 (R)-BPO-27 (R)-BPO-27是有效的CFTR抑制剂,IC50值为4nM。
  14. GC41233 (R)-MG132 A potent proteasome inhibitor
  15. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质,为有效的,广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。
  16. GC13136 (S)-Crizotinib Potent MTH1 inhibitor
  17. GC14820 (S)-Naproxen non-selective COX inhibitor
  18. GC15015 (±)-Bay K 8644 L-type Ca2+-channel activator
  19. GC35068 1-Monomyristin 1-Monomyristin 提取自 Serenoa repens,抑制 2-油酰甘油的水解 (IC50=32 μM) 和脂肪酸酰胺水解酶 (FAAH) 活性 (IC50=18 μM)。1-Monomyristin 对金黄色葡萄球菌和聚集性放线菌有抗菌活性,对白色念珠菌也有抗真菌活性。
  20. GC17295 10058-F4 C-Myc-Max dimerization inhibitor
  21. GC14918 10074-G5 c-Myc inhibitor
  22. GC11720 17-AAG (KOS953) Hsp90 inhibitor
  23. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.
  24. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester
  25. GC15084 2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent
  26. GC30011 20-Deoxyingenol 20-去氧巨大戟萜醇是一天然化合物。
  27. GC35112 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene,一种天然紫檀芪类似物,通过诱导细胞凋亡 (apoptosis) 和自噬 (autophagy),有效抑制人结肠癌细胞的生长 (对 COLO 205,HCT-116 和 HT-29 细胞的 IC50 分别为 9.0,40.2 和 70.9 μM)。3'-Hydroxypterostilbene 抑制 PI3K/Akt/mTOR/p70S6K 和 p38MAPK 途径并激活 ERK1/2,JNK1/2 MAPK途径。
  28. GC12791 3,3'-Diindolylmethane Anticancer and antineoplastic agent
  29. GC10710 3-Methyladenine Class III PI3K inhibitor
  30. GC32767 3BDO 3BDO是一种新型mTOR激活剂,也能抑制自噬。
  31. GC39658 4,4'-Dimethoxychalcone 4,4'-Dimethoxychalcone 可从植物当归中分离得到,是一种天然自噬 (autophagy) 诱导剂,具有抗衰老活性。
  32. GC42414 4-hydroxy Tolbutamide 4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker.
  33. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin 是一种查尔酮化合物,来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK,JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性,包括抗菌,抗癌,抗逆转录酶,抗结核,抗疟,抗炎和抗氧化活性。
  34. GC13104 4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction
  35. GC30785 4E2RCat 4E2RCat是eIF4E-eIF4G相互作用的抑制剂,IC50值为13.5μM。
  36. GC10468 4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor
  37. GC10946 5-Azacytidine A DNA methyltransferase inhibitor
  38. GN10241 5-Methoxypsoralen Extracted from Cnidium monnieri (L.) cuss;Suitability:Boiling ethanol,acetic acid,propylene glycol,chloroform and benzene;Store the product in sealed,cool and dry condition
  39. GC16267 6-Hydroxydopamine hydrobromide An antagonist of the neurotransmitter dopamine
  40. GN10228 6-Shogaol Extracted from effective components of ginger。;Store the product in sealed, cool and dry condition
  41. GN10449 7-Ethyl-10-hydroxycamptothecin TOPO I inhibitor
  42. GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor
  43. GC17710 A-317491

    P2X3 and P2X2/3 receptor antagonist

  44. GC35211 A-317491 sodium salt hydrate A-317491 sodium salt hydrate 是非核苷酸类P2X3和P2X2/3受体拮抗剂,能抑制由其介导的钙流。
  45. GC15014 A-867744 Allosteric Modulator
  46. GC11200 A23187

    Ca2+ ionophore

  47. GC14069 ABT-199

    Bcl-2 inhibitor,potent and selective

  48. GC17234 ABT-737

    Bcl-2 inhibitor

  49. GC15875 ABT-751 (E7010) Inhibitor of microtubule polymerization,antimitotic
  50. GC12422 ABT-888 (Veliparib) A potent PARP inhibitor
  51. GC10871 AC 55649 RARβ2 agonist, potent and selective

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