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Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC46008 (±)-Thalidomide-d4
  3. GC34960 (+)-Talarozole (+)-Talarozole 是视黄酸代谢的有效抑制剂,来自专利 WO 1997049704 A1。
  4. GC10603 (-)-epicatechin gallate major catechin in green tea
  5. GC17242 (-)-epigallocatechin green tea epicatechin
  6. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent
  7. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606transisomer是一种FXR激动剂,在FRET和M1H测定中对于FXR的EC50值分别为18和29nM。
  8. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypolaceticacid(AT-101(aceticacid))是天然产物Gossypol的左旋异构体。AT-101结合到Bcl-2,Mcl-1和Bcl-xL蛋白,Ki值分别为260±30nM,170±10nM和480±40nM。
  9. GC31665 (R)-BPO-27 (R)-BPO-27是有效的CFTR抑制剂,IC50值为4nM。
  10. GC41233 (R)-MG132 The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins.
  11. GC13136 (S)-Crizotinib Potent MTH1 inhibitor
  12. GC14820 (S)-Naproxen non-selective COX inhibitor
  13. GC15015 (±)-Bay K 8644 L-type Ca2+-channel activator
  14. GC35068 1-Monomyristin 1-Monomyristin 提取自 Serenoa repens,抑制 2-油酰甘油的水解 (IC50=32 μM) 和脂肪酸酰胺水解酶 (FAAH) 活性 (IC50=18 μM)。1-Monomyristin 对金黄色葡萄球菌和聚集性放线菌有抗菌活性,对白色念珠菌也有抗真菌活性。
  15. GC17295 10058-F4 C-Myc-Max dimerization inhibitor
  16. GC14918 10074-G5 c-Myc inhibitor
  17. GC11720 17-AAG (KOS953) Hsp90 inhibitor
  18. GC15084 2-Methoxyestradiol (2-MeOE2)

    Apoptotic, antiproliferative and antiangiogenic agent

  19. GC35112 3’-Hydroxypterostilbene 3'-Hydroxypterostilbene,一种天然紫檀芪类似物,通过诱导细胞凋亡 (apoptosis) 和自噬 (autophagy),有效抑制人结肠癌细胞的生长 (对 COLO 205,HCT-116 和 HT-29 细胞的 IC50 分别为 9.0,40.2 和 70.9 μM)。3'-Hydroxypterostilbene 抑制 PI3K/Akt/mTOR/p70S6K 和 p38MAPK 途径并激活 ERK1/2,JNK1/2 MAPK途径。
  20. GC12791 3,3'-Diindolylmethane Anticancer and antineoplastic agent
  21. GC10710 3-Methyladenine Class III PI3K inhibitor

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