Tyrosine Kinase - Signaling Pathways

Cat.No. Product Name Information

GC41183 α-Carotene

α-Carotene is a precursor of vitamin A that has been found in various fruits and vegetables.

GC38006 β-Hydroxyisovalerylshikonin Beta-hydroxyisovalerylshikonin 是一种从Lithospermium radix 中分离出的天然产物，是一种有效的 PTK 抑制剂，对 EGFR 和 v-Src 受体作用的 IC50 分别为 0.7 μM 和 1 μM。Beta-hydroxyisovalerylshikonin 对多种肿瘤细胞系均有抑制作用，能高效诱导 NCI-H522 和 DMS114 细胞的死亡。

GC41653 (±)16(17)-DiHDPA (±)16(17)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid.

GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.

GC13944 (5Z)-7-Oxozeaenol

TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

GC17800 (E)-FeCP-oxindole VEGFR-2 inhibitor

GC61807 (E/Z)-AG490

(E/Z)-AG490((E/Z)-TyrphostinAG490)是(E)-AG490和(Z)-AG490的消旋体。(E)-AG490是一种酪氨酸激酶抑制剂，可抑制EGFR，Stat-3和JAK2/3。

GC14729 (R)-Crizotinib C-MET/ALK inhibitor,potent and ATP-competitve

GC19012 (R)-GNE-140

A TRK kinase (TKI) inhibitor

GC13136 (S)-Crizotinib Potent MTH1 inhibitor

GC13344 (Z)-FeCP-oxindole VEGFR-2 inhibitor

GC62291 (Z)-Orantinib (Z)-Orantinib ((Z)-SU6668) 是一种有效，选择性，具有口服活性和 ATP 竞争性的 Flk‐1/KDR，PDGFRβ 和 FGFR1 抑制剂，IC50 值分别为 2.1，0.008 和 1.2 µM。(Z)-Orantinib 是有效的抗血管生成和抗肿瘤剂，可诱导已建立的肿瘤消退。

GC12172 1-Naphthyl PP1 Src family kinases inhibitor

GC34119 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) 1-NaphthylPP1(1-NA-PP1)盐酸盐是src家族抑制剂，对v-Src，c-Fyn，c-Abl，CDK2和CAMKII的IC50分别为1.0，0.6，0.6，18和22μM。

GC11696 1-NM-PP1 Pp60c-src inhibitor

GC42026 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine.

GC35053 123C4 123C4 是一种有效、选择性的，竞争性受体酪氨酸激酶 EPHA4 激动剂，Ki 值为 0.65 μM.

GC46474 18-Deoxyherboxidiene

GC33087 2,4-Pyrimidinediamine with linker 2,4-Pyrimidinediaminewithlinker是专利WO2013055780A1(71页，intermediate2),激酶抑制剂，含linker结构。

GC33519 2,5-Dihydroxybenzoic acid 2,5-Dihydroxybenzoicacid是苯甲酸的代谢物，也是纤维母细胞生长因子(fibroblastgrowthfactor)的强效抑制剂。