Hedgehog
Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.
Products for Hedgehog
- Cat.No. 产品名称 Information
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GC66390
3-epi-Vitamin D3
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4) 是维生素 D3 类似物,是一种 Hedgehog pathway 抑制剂,在U87MG 细胞中测定的 IC50 为 39.2 μM。
- GC64134 Hh-Ag1.5 Hh-Ag1.5 (SAg1.5) 是一种有效的 Hedgehog (Hh) 激动剂,EC50 为 1 nM。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态,从而挽救了肝衰竭。
- GC49651 19-alkyne Cholesterol An alkyne derivative of cholesterol for click chemistry
- GC47570 Lipoxygenin An inhibitor of 5-LO
- GC47474 Itraconazole-d5 An internal standard for the quantification of itraconazole
- GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor
- GC39359 Ciliobrevin D Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor cytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocks Hedgehog (Hh) signaling.
- GC37573 RU-SKI 43 An inhibitor of hedgehog acyltransferase
- GC45090 Triparanol An inhibitor of DHCR24
- GC44855 RU-SKI 43 (hydrochloride) An inhibitor of hedgehog acyltransferase
- GC44458 N-Palmitoyl-L-Aspartate A natural N-acylaspartate
- GC44321 Nat-20(S)-yne Nat-20(S)-OHC with a terminal alkyne group
- GC43809 Hedgehog Antagonist VIII An inhibitor of hedgehog pathway signaling
- GC43346 Cyclopamine-KAAD A potent inhibitor of hedgehog signaling
- GC18475 Robotnikinin A direct inhibitor of sonic hedgehog
- GC11217 CUR 61414 A potent inhibitor of hedgehog-induced activity
- GC17713 Oxy-16 A synthetic oxysterol
- GC13630 MK-4101 A Smoothened receptor antagonist
- GC12068 SAG An agonist of Smoothened
- GC15422 20(S)-Hydroxycholesterol An allosteric Smo agonist
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GC15284
U 18666A
U18666A抑制3β羟基甾醇-Δ(24)还原酶 (DHCR24)活性,阻止胆固醇从晚期核内体和溶酶体外流。
- GC15889 SANT-1 An antagonist of Smoothened
- GC12429 AY 9944 dihydrochloride A cholesterol synthesis inhibitor
- GC14715 AZ 12080282 dihydrochloride 刺猬抑制剂
- GC11111 Jervine An inhibitor of the hedgehog signaling pathway
- GC11476 Ciliobrevin A A hedgehog pathway inhibitor
- GC11045 HPI 1 A Hedgehog pathway inhibitor
- GC11193 SANT-2 A Smoothened receptor antagonist
- GC15256 JK 184 An inhibitor of downstream hedgehog signaling
- GC15683 LY2940680 A Smo antagonist
- GC17153 CHIR-99021 (CT99021) HCl A selective GSK3 inhibitor
- GC13280 PF-5274857 PF-5274857 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂,IC50 为 5.8 nM,Ki 为 4.6 nM。 PF-5274857 具有研究肿瘤类型的潜力,包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
- GC13441 Cyclopamine An inhibitor of hedgehog signaling
- GC10359 GANT61 Antagonist of Gli transcription factors, involved in Hedgehog signaling
- GC15064 Purmorphamine Purmorphamine is the first small molecule agonist developed for Smoothened protein.
- GC16789 GANT 58 An inhibitor of Gli transcription
- GC10493 GDC-0449 (Vismodegib) GDC-0449 (Vismodegib) (GDC-0449) 是一种具有口服活性的hedgehog 通路抑制剂,IC50 为3 nM。 GDC-0449 (Vismodegib) 还抑制 P-gp、ABCG2,IC50 值分别为 3.0 μM 和 1.4 μM。