Xanthine Oxidase(黄嘌呤氧化酶)

Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Xanthine oxidase belongs to the molybdenum-protein family containing one molybdenum, one of the flavin adenine dinucleotides (FAD), and two iron-sulfur (2Fe-2S) centers of the ferredoxin type in each of its two independent subunits. The enzyme contains two separated substrate-binding sites. XO catalysed the oxidation of hypoxanthine to xanthine and subsequently to uric acid.

Xanthine oxidase inhibitors (XOIs) are typically used in the treatment of nephropathy and renal stone diseases linked to hyperuricemia.

Products for Xanthine Oxidase

Cat.No. 产品名称 Information
GC52049 Myricetin 3-galactoside A flavonoid with diverse biological activities
GC64122 Tigulixostat Tigulixostat (LC350189) 是一种具有口服活性的非嘌呤选择性黄嘌呤氧化酶 (xanthine oxidase) 抑制剂。Tigulixostat 降低尿酸的产生，可用于痛风和高尿酸血症研究。
GC39050 Prudomestin Prudomestin，从 Prunus domestica 心材中分离得到，具有很强的黄嘌呤氧化酶 (XO) 抑制活性(IC50≈6?µM)。
GC38116 Purpurogallin A phenol
GC36903 Phytic acid dodecasodium salt hydrate Phytic acid (Inositol polyphosphate, Inositol hexakisphosphate) is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. Phytic acid inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
GC36036 Febuxostat D9 An internal standard for the quantification of febuxostat
GC42578 6-Formylpterin An intracellular generator of hydrogen peroxide
GC41531 Anacardic Acid Triene A polyunsaturated form of anacardic acid
GC33813 Xanthine oxidase-IN-1 Xanthine oxidase-IN-1 是一种黄嘌呤氧化酶抑制剂，提取自专利 WO2008126898A1，第 68 页，化合物实施例 3，IC50 为 6.5 nM。
GC10827 Oxipurinol An inhibitor of xanthine oxidase and active metabolite of allopurinol
GC14930 Benzbromarone An inhibitor of URAT1
GC16127 Topiroxostat An inhibitor of xanthine oxidoreductase
GC15322 Allopurinol Inhibitor of xanthine oxidase
GC16319 Febuxostat An inhibitor of the oxidized and reduced forms of xanthine oxidase
GN10158 Baicalein A flavonoid with diverse biological activities
GN10554 Phytic acid 植酸是种子和谷物的磷储存化合物。