Lipoxygenase(脂氧合酶)
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Products for Lipoxygenase
- Cat.No. 产品名称 Information
- GC69434 Masoprocol Masoprocol (meso-Nordihydroguaiaretic acid) 是一种有效且具有口服活性的脂氧合酶 (lipoxygenase) 抑制剂。Masoprocol 显示出抗高血糖活性。 Masoprocol 降低体内葡萄糖浓度和肝脏甘油三酯浓度。Masoprocol具有研究II型糖尿病的潜力。
- GC69335 KKII5 KKII5 是一种有效的脂氧合酶 LOX-1 抑制剂,IC50 为 19 μM。KKII5 抑制脂质过氧化。
- GC68641 ALOX15-IN-1 ALOX15-IN-1 (compound 8b) 是一种有效且选择性的兔和人 ALOX15 亚油酸加氧酶 (linoleate oxygenase) 活性抑制剂,对 ALOX15 直系同源物亚油酸 (LA) 和花生四烯酸 (AA) 的 IC50 分别为 0.04 和 2.06 μM。
- GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid
- GC66031 5-LOX-IN-1 5-LOX-IN-1 (compound 2b) 是 5-Lipoxygenase (5-LOX) 的抑制剂,IC50 值为 2.3 μM。5-LOX-IN-1 可用于癌症的研究。
- GC64621 4-Nitrocatechol 4-Nitrocatechol 是一种有效的脂氧合酶 (lipoxygenase) 抑制剂。
- GC52105 Montelukast A CysLT1 receptor antagonist
- GC49894 15(S)-HETE-d8 ethyl ester An internal standard for the quantification of 15(S)-HETE ethyl ester
- GC49849 3-Aminosalicylic Acid A salicylic acid derivative
- GC49778 Etheroleic Acid A divinyl ether oxylipin
- GC49758 CAY10788 A CysLT1 receptor antagonist
- GC64078 3-O-Acetyl-11-hydroxy-beta-boswellic acid 3-O-Acetyl-11-hydroxy-beta-boswellic acid 是一种5-脂氧合酶 (5-LO) 抑制剂。
- GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
- GC49696 FPL 55712 (sodium salt) A leukotriene receptor antagonist
- GC49597 Leukotriene B4-d5 An internal standard for the quantification of LTB4
- GC49590 Docosahexaenoic Acid 1,2,3,4-13C An internal standard for the quantification of DHA
- GC49386 Tepoxalin A dual inhibitor of COX and 5-LO
- GC49364 3-Hydroxycoumarin A coumarin with diverse biological activities
- GC49356 17(S)-HDoTE A metabolite of adrenic acid
- GC49098 Olsalazine-13C6 An internal standard for the quantification of olsalazine
- GC48993 Protectin D1-d5 An internal standard for the quantification of protectin D1
- GC48972 Resolvin E2 A specialized pro-resolving mediator
- GC48893 Carbazomycin B A bacterial metabolite with diverse biological activities
- GC48850 Carbazomycin C A bacterial metabolite with diverse biological activities
- GC48659 Umbelliprenin A prenylated coumarin with diverse biological activities
- GC48267 Zileuton-d4 An internal standard for the quantification of zileuton
- GC48045 Resolvin E4 A specialized pro-resolving mediator
- GC48042 Resolvin D2-d5 An internal standard for the quantification of RvD2
- GC48041 Resolvin D1-d5 An internal standard for the quantification of RvD1
- GC48035 RCTR1 A specialized pro-resolving mediator
- GC47716 Myxochelin A A microbial metabolite with diverse biological activities
- GC47575 Loratadine-d5 An internal standard for the quantification of loratadine
- GC47570 Lipoxygenin An inhibitor of 5-LO
- GC47569 Lipoxin A4-d5 An internal standard for the quantification of Lipoxin A4
- GC47560 Leukotriene E4-d5 An internal standard for the quantification of leukotriene E4
- GC47559 Leukotriene D4-d5 An internal standard for the quantification of LTD4
- GC47556 Leukotriene B4-d4 An internal standard for the quantification of leukotriene B4
- GC47323 Etofenamate-d4 An internal standard for the quantification of etofenamate
- GC47312 Etherolenic Acid A divinyl ether oxylipin
- GC46798 Adapalene-d3 An internal standard for the quantification of adapalene
- GC46753 9(S),12(S),13(S)-TriHOME An oxylipin
- GC46732 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid A metabolite of DPA with anti-inflammatory properties
- GC46679 5(S)-HETE-d8 An internal standard for the quantification of 5-HETE
- GC46442 15(S)-HETE-d8 An internal standard for the quantification of 15(S)-HETE
- GC46420 13(S)-HODE-d4 An internal standard for the quantification of 13-HODE
- GC46418 12-oxo-13-HOME An oxylipin
- GC61180 Phenidone Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
- GC46105 Butyrolactone II A fungal metabolite
- GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO
- GC39013 FPL 62064 FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.