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Home >> Signaling Pathways >> Proteases >> Lactate Dehydrogenase

Lactate Dehydrogenase(乳酸脱氢酶)

Lactate Dehydrogenase (LDH), which catalyzes the inter-conversion of pyruvate and lactate.

Mammalian lactate dehydrogenase (LDH) comprises three major families of conserved enzymes that catalyse the reversible interconversion of pyruvate and lactate, a key metabolic step in glycolysis and other metabolic pathways. At least five LDH tetrameric isozymes are reported in somatic mammalian tissues, comprising LDHA and LDHB subunits, whereas LDHC4 is found only in mature testis and spermatozoa, where it is required for male fertility. Lactate dehydrogenase catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. At high concentrations of lactate, the enzyme exhibits feedback inhibition, and the rate of conversion of pyruvate to lactate is decreased. Dihydroorotate dehydrogenase (DHODH) is a key enzyme that catalyzes the oxidation of dihydroorotate (DHO) to produce orotate, a key step in pyrimidine biosynthesis.

Products for  Lactate Dehydrogenase

  1. Cat.No. 产品名称 Information
  2. GC68710 AXKO-0046 dihydrochloride AXKO-0046 dihydrochloride，吲哚衍生物，是 LDHB 选择性抑制剂。AXKO-0046 dihydrochloride 具有 LDHB 抑制活性，EC50 值为 42 nM。AXKO-0046 dihydrochloride 可用于癌症代谢的研究。
  3. GC63795 LDHA-IN-3 LDHA-IN-3 作为一种硒苯化合物，是一种有效的非竞争性乳酸脱氢酶(LDHA) 抑制剂(IC50=145.2 nM)。LDHA-IN-3 可用于癌症研究。
  4. GC39392 Isomalt Isomalt (Palatinitol) is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. Isomalt stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying.
  5. GC50151 NHI 2 An inhibitor of LDHA
  6. GC39279 hDHODH-IN-1 hDHODH-IN-1 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with anti-inflammatory effect.
  7. GC38604 Glomeratose A Glomeratose A 是一种乳酸脱氢酶 lactate dehydrogenase 抑制剂，是从远志 Polygala tenuifolia 分离的。
  8. GC38463 ASLAN003 A DHODH inhibitor
  9. GC35106 3-Dehydrotrametenolic acid 3-?Dehydrotrametenolic acid，分离于茯苓菌核，是一种乳酸脱氢酶 (LDH) 抑制剂。3-?Dehydrotrametenolic acid 促进体外脂肪细胞分化，在体内起胰岛素增敏剂的作用。3-?Dehydrotrametenolic acid 诱导细胞凋亡，具有抗癌活性。
  10. GC34011 FX-11 (LDHA Inhibitor FX11) FX-11 (LDHA Inhibitor FX11) 是一种有效的、选择性的、可逆的和竞争性的乳酸脱氢酶 A (LDHA) 特异性抑制剂，Ki 为 8 μM. FX-11（LDHA Inhibitor FX11）能有效激活PKM2（丙酮酸激酶M2）。 FX-11 (LDHA Inhibitor FX11) 降低 ATP 水平并诱导氧化应激、ROS 产生和细胞死亡。 FX-11 (LDHA Inhibitor FX11) 在淋巴瘤和胰腺癌异种移植物中显示出抗肿瘤活性。
  11. GC32993 (S)-GNE-140 (S)-GNE-140是活性较小的GNE-140的对映体，能够抑制乳酸脱氢酶A(LDHA)。
  12. GC32931 LDH-IN-1 LDH-IN-1是一种新的基于吡唑的人乳酸脱氢酶(LDH)抑制剂，对于LDHA和LDHB的IC50值分别为32和27nM。
  13. GC32838 BAY-2402234 A DHODH inhibitor
  14. GC32694 GNE-140 racemate GNE-140racemate是(R)-GNE-140和(S)-GNE-140的外消旋混合物。(R)-GNE-140是有效的乳酸脱氢酶A(LDHA)抑制剂。
  15. GC18183 Nifurtimox An antiprotozoal agent
  16. GC19012 (R)-GNE-140 (R)-GNE-140 是一种有效的乳酸脱氢酶 A (LDHA) 抑制剂，对 LDHA 和 LDHB 的 IC50 分别为 3 nM 和 5 nM； (R)-GNE-140 的效力是 S 对映体的 18 倍。
  17. GC13464 GSK 2837808A

    GSK2837808A is a selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 2.
  18. GC14851 Vidofludimus An immunosuppressive drug that inhibits DHODH

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