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PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GC17330 (+)-Usniacin Naturally occurring dibenzofuran derivative
  3. GC62122 (E)-Akt inhibitor-IV (E)-Akt inhibitor-IV ((E)-AKTIV) 是一种 PI3K-Akt 抑制剂,具有显著的细胞毒性。
  4. GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 是 (E)-GSK-3β inhibitor 1 和 (Z)-GSK-3β inhibitor 1 的消旋体。GSK-3β inhibitor 1 (compound 3a) 是糖原合成酶激酶 3β (GSK-3β)的抑制剂,可用于糖尿病的研究,其对 GSK-3β 的 IC50 值为 4.9 nM。
  5. GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体,对DNA-PK的IC50值为7-30nM。
  6. GC62450 (S)-PI3Kα-IN-4 (S)-PI3Kα-IN-4 是一种有效的 PI3Kα 抑制剂,IC50 为 2.3 nM。(S)-PI3Kα-IN-4 对 PI3Kα 的选择性分别比 PI3Kβ,PI3Kδ 和 PI3Kγ 高38.3,4.25 和 4.93 倍。(S)-PI3Kα-IN-4 可用于癌症的研究。
  7. GC35037 1,3-Dicaffeoylquinic acid 1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物,具有抗氧化活性和自由基清除活性。
  8. GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable
  9. GC41992 1-Deoxynojirimycin (hydrochloride) 1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II.
  10. GC42018 1-O-Octadecyl-2-O-methyl-sn-glycerol 1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA).
  11. GC13006 10-DEBC hydrochloride Akt inhibitor
  12. GC41979 17β-hydroxy Wortmannin 17β-hydroxy Wortmannin is an analog of wortmannin.
  13. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.
  14. GC46531 2-Amino-5-bromo-6-chloropyrazine
  15. GC35124 3α-Hydroxymogrol 3α-Hydroxymogrol 是从罗汉果中得到的三萜类化合物,为有效的 AMPK 激活剂,可增强 AMPK 的磷酸化水平。
  16. GC42237 3,5-dimethyl PIT-1 PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN.
  17. GC13992 3-Guanidinopropionic Acid AMPK stimulator
  18. GC10710 3-Methyladenine Class III PI3K inhibitor
  19. GC32767 3BDO 3BDO是一种新型mTOR激活剂,也能抑制自噬。
  20. GC12078 3CAI AKT inhibitor
  21. GC16960 4,5,6,7-Tetrabromobenzimidazole CK2 inhibitor

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