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Home >> Signaling Pathways >> Others >> Imidazoline Receptors

Imidazoline Receptors(咪唑啉受体)

Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three classes of imidazoline receptors: I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected), I2 receptor - an allosteric binding site of monoamine oxidase and is involved in pain modulation and neuroprotection, I3 receptor - regulates insulin secretion from pancreatic beta cells. Activated I1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengers arachidonic acid and downstreameicosanoids. In addition, the sodium-hydrogen antiporter is inhibited, and enzymes of catecholamine synthesis are induced. The I1-imidazoline receptor may belong to the neurocytokine receptorfamily, since its signaling pathways are similar to those of interleukins.

Products for  Imidazoline Receptors

  1. Cat.No. 产品名称 Information
  2. GC11588 2-BFI hydrochloride I2配体
  3. GC16831 Agmatine sulfate A polyamine metabolite
  4. GC14934 AGN 192403 hydrochloride I1 imidazoline receptor
  5. GN10492 Allantoin A product of purine and uric acid metabolism
  6. GC15700 BU 224 hydrochloride BU 224 hydrochloride 是一种选择性和高亲和力的咪唑啉 I2 受体配体，Ki 为 2.1 nM。
  7. GC15202 BU 226 hydrochloride BU 226 hydrochloride 是一种选择性咪唑啉 2 (I2) 受体配体，对 I2 的 Ki 为 1.4 nM，对 I1 的 IC50 为 534.5 nM。
  8. GC11580 BU 239 hydrochloride Imidazoline receptors-selective antagonist
  9. GC31094 CR4056 CR4056是一个选择性的人重组MAO-A抑制剂，其IC50值为202.7nM。CR4056也是咪唑啉-2受体(I2R)的配体，其IC50值为596nM。
  10. GC15384 Harmane A β-carboline with diverse biological activities
  11. GC69206 Harmane-d Harmane-d 是 Harmane 的氘代物。Harmane，一种 β-咔啉生物碱 (BCA)，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。Harmane 对 I1 咪唑啉受体 (I1-Imidazoline receptor, IC50=30 nM) 的选择性是对 α2-肾上腺素受体 (IC50=18 μM) 的 1000 倍。Harmane 还是有效和选择性的单胺氧化酶抑制剂 (对 MAO A/B 的 IC50 值分别为 0.5 μM 和 5 μM)。
  12. GC63754 Harmane-d1 Harmane-d1 是 Harmane 的氘代物。Harmane，一种 β-咔啉生物碱 (BCA)，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。Harmane 对 I1 咪唑啉受体 (I1-Imidazoline receptor, IC50=30 nM) 的选择性是对 α2-肾上腺素受体 (IC50=18 μM) 的 1000 倍。Harmane 还是有效和选择性的单胺氧化酶抑制剂 (对 MAO A/B 的 IC50 值分别为 0.5 μM 和 5 μM)。
  13. GC12629 Moxonidine An imidazoline I1 and α2A-adrenergic receptor agonist
  14. GC11198 Moxonidine hydrochloride An imidazoline I1 and α2A-adrenergic receptor agonist
  15. GC60325 Rilmenidine An antihypertensive agent
  16. GC13017 Rilmenidine Phosphate An antihypertensive agent
  17. GC14958 RS 45041-190 hydrochloride Highly selective I2 imidazoline receptor ligand

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