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Ferroptosis

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

  1. Cat.No. Product Name Information
  2. GC16081 (-)-epicatechin inducer of pancreatic β-cell regeneration
  3. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent
  4. GC34980 (E)-Ferulic acid (E)-Ferulic acid 是阿魏酸 (Ferulic acid) 的异构体,阿魏酸是芳香族化合物,在植物细胞壁中丰富。 (E)-Ferulic acid 引起 β-连环蛋白 (β-catenin) 的磷酸化,导致蛋白酶体降解,增加促凋亡因子 Bax 的表达并降低促存活因子存活蛋白的表达。(E)-Ferulic acid 可以有效去除活性氧 (ROS) 和抑制脂质过氧化。(E)-Ferulic acid 在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。
  5. GA11210 (H-Cys-OH)2 (H-Cys-OH)2
  6. GC11786 Acetylcysteine

    Antioxidant;mucolytic agent

  7. GC15130 Alogliptin (SYR-322)

    DPP-4 inhibitor,potent and highly selective

  8. GC35398 Arteannuin B Arteannuin B,与青蒿素共同存在,青蒿素是中药青蒿的有效抗疟原理。
  9. GC35399 Artefenomel Artefenomel (OZ439) 是一种合成的含有青蒿素药效团的抗疟疾药物。Artefenomel (OZ439) 是一种长效青蒿素相关化合物。
  10. GN10647 Artemisinine Extracted from Artemisia annua L.;Suitability:Acetone,benzene,chloroform,ethyl acetate and acetic acid;Store the product in sealed,cool and dry condition
  11. GC10889 Artesunate

    derivative of the natural product artemisinin

  12. GC14038 Atorvastatin Calcium HMG-CoA reductase inhibitor
  13. GN10158 Baicalein Lipoxygenases inhibitor
  14. GC11572 Bardoxolone methyl

    IKK inhibitor, potent antioxidant inflammation modulator

  15. GC10345 Bay 11-7085 NK-κB activation inhibitor
  16. GC12698 BAY 87-2243 HIF-1 inhibitor,potent and selective
  17. GC34070 Brusatol (NSC 172924)

    Brusatol(NSC172924),从Bruceajavanica植物中分离的,可抑制Nrf2。

  18. GC30067 Butylhydroxyanisole (Butylated hydroxyanisole) Butylhydroxyanisole是一种抗氧化剂,由两种异构有机化合物构成,用作食品添加剂和防腐剂。
  19. GC32723 CDDO-Im (RTA-403) CDDO-Im(CDDO-imidazolide)是Nrf2和PPAR的活化剂,对PPARα和PPARγ的Ki分别为232nM和344nM。
  20. GC43231 Cerivastatin (sodium salt) Cerivastatin is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (Ki = 1.3 nM).
  21. GC35692 Chrysosplenetin Chrysosplenetin 是青蒿 (Artemisia annua) 和其他几种中草药中的多甲氧基化黄酮类化合物之一。 Chrysosplenetin 抑制P-gp 活性并逆转由青蒿素 (ART) 诱导的上调的 P-gp 和 MDR1 水平。 Chrysosplenetin 显着增强 ART 在大鼠血浆水平和抗疟疾功效,部分因为其对大鼠 CYP3A 的非竞争性抑制作用。

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