Metabolism - Signaling Pathways

Cat.No. Product Name Information

GC45239 δ4-Abiraterone δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone.

GC15975 α-Estradiol Endogenous estrogen receptor ligand

GC14406 (±)-Acetylcarnitine chloride weak cholinergic agonist; intermediates in lipid metabolism

GC15834 (±)-Decanoylcarnitine chloride intermediate in lipid metabolism

GC17351 (±)-Hexanoylcarnitine chloride

important intermediates in lipid metabolism

GC16427 (±)-Lauroylcarnitine chloride important intermediates in lipid metabolism

GC10056 (±)-Myristoylcarnitine chloride cholinergic agonist; important intermediates in lipid metabolism

GC13909 (±)-Octanoylcarnitine chloride homolog of acetylcarnitine chloride

GC12551 (±)-Propionylcarnitine chloride homolog of acetylcarnitine chloride

GC12404 (+)-Ketoconazole Potent inhibitor of cytochrome P450c17

GC30424 (-)-Cephaeline dihydrochloride (NSC 32944)

(-)-Cephaelinedihydrochloride是Cephaelinedihydrochloride的一种对映异构体。Cephaelinedihydrochloride是选择性的CYP2D6抑制剂，IC50为121μM。

GC16081 (-)-epicatechin inducer of pancreatic β-cell regeneration

GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent

GC14520 (-)-p-Bromotetramisole Oxalate ALP inhibitor, potent and non-specific

GC13751 (3S,5S)-Atorvastatin (sodium salt) negetive control of Atorvastatin, HMG-CoA reductase inhibitor

GC34980 (E)-Ferulic acid (E)-Ferulic acid 是阿魏酸 (Ferulic acid) 的异构体，阿魏酸是芳香族化合物，在植物细胞壁中丰富。 (E)-Ferulic acid 引起 β-连环蛋白 (β-catenin) 的磷酸化，导致蛋白酶体降解，增加促凋亡因子 Bax 的表达并降低促存活因子存活蛋白的表达。(E)-Ferulic acid 可以有效去除活性氧 (ROS) 和抑制脂质过氧化。(E)-Ferulic acid 在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。

GA11210 (H-Cys-OH)2 (H-Cys-OH)2

GC34984 (R)-(-)-Rolipram (R)-(-)-Rolipram是cAMP-特异的PDE4抑制剂，IC50为220nM。在抑制PDE4膜结合实验中其抑制性高于(+)-rolipram 2.5倍。

GC14486 (S)-Mephenytoin

substrate of the cytochrome P450 (CYP) isoform CYP2C19

GC17913 1-Deazaadenosine adenosine deaminase inhibitor